Content
Finish last all year long
Reviewed by Kelly Brown MD, MBA
Written by Geoffrey C. Whittaker
Published 04/17/2022
Updated 05/06/2024
Premature ejaculation, or PE, is a common sexual performance issue affecting up to 39 percent of adult men. As you might suspect, guys with PE consider every treatment avenue, including over-the-counter topicals, prescription medications and even purported vitamins for premature ejaculation.
Currently, there’s very little scientific evidence to suggest that vitamins for premature ejaculation are effective. While some studies do suggest that nutrient deficiencies may play a role in the development of PE, taking a supplement would only help in the rare case you’re dealing with a true deficiency.
Below, we’ll explain what PE is and the factors thought to cause it. We’ll also discuss options for treating premature ejaculation, including the latest studies on vitamins, minerals and other natural treatments.
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Over the years, researchers have looked at various nutritional factors that could be involved in the development of PE.
Currently, research suggests a variety of physical and psychological factors, like:
Abnormal levels of certain hormones that control behavior, brain activity and sexual functions, such as luteinizing hormone, serotonin, prolactin and thyroid-stimulating hormone
Some types of infections and inflammation affecting your prostate or urethra that can negatively affect your sex life
Psychological issues that can contribute to PE, including anxiety, depression, guilt, stress and lack of sexual self-confidence
Certain life events, such as relationship issues or a personal history of abuse
Our guide to premature ejaculation discusses these factors and the roles they may play in PE in more detail.
While vitamins aren’t on this list, they might directly or indirectly contribute to sexual function issues. This means they could be considered treatment options for guys dealing with PE.
Should you take a vitamin or supplement for PE? And if so, which one? The answer is a bit complicated.
What are the best delayed ejaculation supplements? They often contain the following vitamins for premature ejaculation:
Vitamin B12
Vitamin D
Zinc
Folic Acid
Biotin
Several studies of PE have looked at the potential effects of vitamins in male sexual function and performance. Interestingly, some have discovered a possible link between low levels of certain vitamins and an increased risk of premature ejaculation.
For example, a 2019 study published in the International Brazilian Journal of Urology found that men with acquired premature ejaculation usually have lower serum vitamin D levels than men with normal sexual function.
The researchers found that low levels of vitamin D were an independent risk factor for PE and suggested that supplementation may be helpful for treating premature ejaculation.
A different study published in the journal Andrologia in 2017 found a link between low levels of vitamin B12 and premature ejaculation.
One study claimed that lifelong premature ejaculation might be improved by consuming zinc, biotin and folic acid. Research suggests that biotin (vitamin B7) plays a role in moderating sexual function and wellness. Meanwhile, zinc supplementation can improve testosterone levels, and folic acid can boost serotonin levels. All of these affect your risk of PE.
But the study’s evidence-based conclusions weren’t airtight — erectile function and the ejaculatory reflex are complicated processes. So although vitamins are essential, they’re not a cure.
While the studies above are interesting, it’s vital to keep in mind that the total amount of research on vitamin levels and premature ejaculation isn’t very large right now.
It’s also important to consider that although low levels of certain vitamins may be associated with PE in a few small studies, there isn’t any evidence suggesting that using vitamin supplements treats PE for everyone.
Moreover, vitamin deficiency is typically rare. So while your levels of magnesium might indeed be so low that they’re causing sexual dysfunction, you need to have that diagnosed first.
On a similar note, there could be a link between vitamin D levels and PE, but consuming a daily vitamin D supplement isn’t a guaranteed fix.
If your premature ejaculation is caused by anxiety, depression or stress, it’s unlikely that taking a vitamin supplement will produce any noticeable improvements in ejaculation time or general sexual function.
If you’re worried about PE and think you might have a vitamin deficiency, the best thing to do is to talk to a healthcare provider.
Most vitamin deficiencies can be diagnosed with simple tests. For instance, it’s easy to check serum levels of vitamin D and vitamin B12 — two nutrients associated with PE — with a blood test.
Taking a vitamin supplement could help if you have premature ejaculation caused by a specific vitamin deficiency, such as low serum levels of vitamin D or B12.
However, if PE is happening because of something other than low levels of certain vitamins, you’ll likely get better results from treatments that specifically address the causes of premature ejaculation.
Currently, the most effective treatments for PE include behavioral techniques, over-the-counter sprays, creams and wipes, and prescription medications.
If you have mild premature ejaculation, you might be able to delay ejaculation and improve your sexual performance by using simple behavioral techniques. This includes the squeeze technique, the stop-start method and exercising pelvic floor muscles (aka Kegals).
These practical approaches can be repeated as needed during sex, helping you last longer and avoid ejaculating too early.
Several over-the-counter medications are available for PE, including sprays, creams and wipes containing topical anesthetics. These treatments work by reducing sensitivity in your penis, allowing you to have more control of ejaculation.
For example, our climax-delay spray contains the anesthetic lidocaine to lower sensitivity without overly numbing your penis. Our guide to lidocaine spray for premature ejaculation goes into more detail about how topical medications for PE work.
Although there’s currently no FDA-approved medication for premature ejaculation, several drugs are used off-label as PE treatments. (Off-label use means a med is prescribed to treat something the U.S. Food and Drug Administration hasn’t approved it for.)
These include antidepressants and erectile dysfunction (ED) medications linked to improvements in sexual stamina.
Right now, the most common prescription drugs for treating PE are selective serotonin reuptake inhibitors, or SSRIs. These medications — generally used to treat depression — work by increasing the activity of the neurotransmitter serotonin (aka “the happy chemical”) in your brain.
Research suggests that serotonin, which regulates your moods and feelings, helps to inhibit the process of orgasm and ejaculation.
PDE5 inhibitors like sildenafil (generic Viagra®) also help to slow down orgasm to treat premature ejaculation. Your healthcare provider may recommend combining this type of medication with an SSRI for optimal results.
Sexual intercourse calls for comfort and confidence. And if your recent sexual experiences have left you feeling self-conscious, premature ejaculation treatment may help.
But it’s unclear whether vitamins are that treatment. Here’s what to keep in mind:
Though low vitamin levels are a potential risk factor for premature ejaculation, they generally aren’t viewed as a major cause.
However, research into the potential link between vitamins and premature ejaculation is still in its early stages, meaning we could find out more in the future.
If you’re affected by PE and think it’s related to a vitamin deficiency, it’s best to talk to your healthcare provider.
They may have you do a blood test to check your vitamin B12 or vitamin D levels and, if appropriate, suggest a vitamin supplement or another medical treatment of premature ejaculation, like an SSRI.
Worried about PE? We offer multiple evidence-based premature ejaculation treatments online. This includes prescription medications and over-the-counter options like our Clockstopper benzocaine wipes and Delay Spray for men.
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Dr. Kelly Brown is a board certified Urologist and fellowship trained in Andrology. She is an accomplished men’s health expert with a robust background in healthcare innovation, clinical medicine, and academic research. Dr. Brown was previously Medical Director of a male fertility startup where she lead strategy and design of their digital health platform, an innovative education and telehealth model for delivering expert male fertility care.
She completed her undergraduate studies at University of North Carolina at Chapel Hill (go Heels!) with a Bachelor of Science in Radiologic Science and a Minor in Chemistry. She took a position at University of California Los Angeles as a radiologic technologist in the department of Interventional Cardiology, further solidifying her passion for medicine. She also pursued the unique opportunity to lead departmental design and operational development at the Ronald Reagan UCLA Medical Center, sparking her passion for the business of healthcare.
Dr. Brown then went on to obtain her doctorate in medicine from the prestigious Northwestern University - Feinberg School of Medicine and Masters in Business Administration from Northwestern University - Kellogg School of Management, with a concentration in Healthcare Management. During her surgical residency in Urology at University of California San Francisco, she utilized her research year to focus on innovations in telemedicine and then served as chief resident with significant contributions to clinical quality improvement. Dr. Brown then completed her Andrology Fellowship at Medical College of Wisconsin, furthering her expertise in male fertility, microsurgery, and sexual function.
Her dedication to caring for patients with compassion, understanding, as well as a unique ability to make guys instantly comfortable discussing anything from sex to sperm makes her a renowned clinician. In addition, her passion for innovation in healthcare combined with her business acumen makes her a formidable leader in the field of men’s health.
Dr. Brown is an avid adventurer; summiting Mount Kilimanjaro in Tanzania (twice!) and hiking the incredible Torres del Paine Trek in Patagonia, Chile. She deeply appreciates new challenges and diverse cultures on her travels. She lives in Denver with her husband, two children, and beloved Bernese Mountain Dog. You can find Dr. Brown on LinkedIn for more information.
Education & Training
Andrology Fellowship, Medical College of Wisconsin
Urology Residency, University of California San Francisco
M.D. Northwestern University Feinberg School of MedicineB.S. in Radiologic Science, Chemistry Minor, University of North Carolina at Chapel Hill
Published as Kelly Walker
Cowan, B, Walker, K., Rodgers, K., Agyemang, J. (2023). Hormonal Management Improves Semen Analysis Parameters in Men with Abnormal Concentration, Motility, and/or Morphology. Fertility and Sterility, Volume 118, Issue 5, e4. https://www.sciencedirect.com/journal/fertility-and-sterility/vol/120/issue/1/suppl/S
Walker, K., Gogoj, A., Honig, S., Sandlow, J. (2021). What’s New in Male Contraception? AUA Update Series, Volume 40. https://auau.auanet.org/content/update-series-2021-lesson-27-what%E2%80%99s-new-male-contraception
Walker, K., Shindel, A. (2019). AUA Erectile Dysfunction Guideline. AUA Update Series, Volume 38. https://auau.auanet.org/content/course-307
Walker, K., Ramstein, J., & Smith, J. (2019). Regret Regarding Fertility Preservation Decisions Among Male Cancer Patients. The Journal of Urology, 201(Supplement 4), e680-e681. https://www.auajournals.org/doi/10.1097/01.JU.0000556300.18991.8e
Walker, K., & Smith, J. (2019). Feasibility Study of Video Telehealth Clinic Visits in Urology. The Journal of Urology, 201(Supplement 4), e545-e545. https://www.auajournals.org/doi/10.1097/01.JU.0000556071.60611.37