Revatio Vs. Sildenafil: Drug Comparison

Revatio^® (sildenafil citrate) is a medication primarily used to treat pulmonary arterial hypertension (PAH). It works by relaxing the blood vessels in the lungs to allow blood to flow more easily, reducing the heart's workload and improving exercise capacity. Revatio specifically targets the pulmonary arteries. It is typically administered orally in tablet form, but can also be given intravenously. Common side effects include headaches, flushing, and indigestion.

Sildenafil is the active ingredient in the brand-name medication Revatio^®. The information below is about brand name Revatio. According to the FDA, “Generic medicines use the same active ingredients as brand-name medicines and work the same way, so they have the same risks and benefits as the brand-name medicines.”

Revatio (sildenafil citrate) is a medication primarily used to treat pulmonary arterial hypertension (PAH). It works by relaxing the blood vessels in the lungs to allow blood to flow more easily, reducing the heart's workload and improving exercise capacity. Revatio specifically targets the pulmonary arteries. It is typically administered orally in tablet form, but can also be given intravenously. Common side effects include headaches, flushing, and indigestion.

Phosphodiesterase-5 (PDE5) inhibitor

Phosphodiesterase-5 (PDE5) inhibitor

Adults:

Revatio (sildenafil citrate) is indicated:

• To treat pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) in adults to improve exercise ability and delay clinical worsening

Pediatric patients (1 to 17 years old):

Revatio (sildenafil citrate) is indicated:

• To treat pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise ability and, in pediatric patients too young to perform standard exercise testing, pulmonary hemodynamics thought to underlie improvements in exercise

Adults:

Revatio (sildenafil citrate) is indicated:

• To treat pulmonary arterial hypertension (PAH) (World Health Organization [WHO] Group I) in adults to improve exercise ability and delay clinical worsening

Pediatric patients (1 to 17 years old):

Revatio (sildenafil citrate) is indicated:

• To treat pulmonary arterial hypertension (PAH) (WHO Group I) to improve exercise ability and, in pediatric patients too young to perform standard exercise testing, pulmonary hemodynamics thought to underlie improvements in exercise

• Typically taken orally three times daily

• Comes in 20 mg tablets; also available as an oral suspension or injection

• Typically taken orally three times daily

• Comes in 20 mg tablets; also available as an oral suspension or injection

Adults:

• Headache

• Indigestion

• Flushing

• Pain in limb

• Muscle pain

• Back pain

• Diarrhea

Children:

• Prolonged erection

Adults:

• Headache

• Indigestion

• Flushing

• Pain in limb

• Muscle pain

• Back pain

• Diarrhea

Children:

• Prolonged erection

• Use with organic nitrates or riociguat

• History of hypersensitivity reaction to sildenafil or any component of the tablet, injection, or oral suspension

• Drug interactions: CYP3A inhibitors, PDE5 inhibitors

• Use with organic nitrates or riociguat

• History of hypersensitivity reaction to sildenafil or any component of the tablet, injection, or oral suspension

• Drug interactions: CYP3A inhibitors, PDE5 inhibitors

• Vasodilation effects may be more common in patients with low blood pressure or on antihypertensive therapy

• Use in pulmonary veno-occlusive disease (PVOD) may cause pulmonary edema and is not recommended

• Hearing or visual impairment: Seek medical attention if sudden decrease or loss of vision or hearing occurs

• Pulmonary hypertension (PH) secondary to sickle cell disease: Sildenafil may cause serious vaso-occlusive crises

• Vasodilation effects may be more common in patients with low blood pressure or on antihypertensive therapy

• Use in pulmonary veno-occlusive disease (PVOD) may cause pulmonary edema and is not recommended

• Hearing or visual impairment: Seek medical attention if sudden decrease or loss of vision or hearing occurs

• Pulmonary hypertension (PH) secondary to sickle cell disease: Sildenafil may cause serious vaso-occlusive crises

*This information is from the label for brand name Revatio^®. See the Full Prescribing Information for more complete information. Sildenafil, the active ingredient in Revatio, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient sildenafil.

*This information is from the label for brand name Revatio^®. See the Full Prescribing Information for more complete information. Sildenafil, the active ingredient in Revatio, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient sildenafil.