FDA approved

Generic for Zoloft®Sertraline

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been simpler. Consult with a licensed healthcare provider to determine whether a medication like sertraline could be right for you.



Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate


Unlimited provider messaging


Unlimited dosage adjustments

What is sertraline?

Sertraline is a prescription drug and was one of the first SSRI (selective serotonin reuptake inhibitor) antidepressants on the US market. Sertraline is marketed under the brand name Zoloft®, which was first approved by the Food and Drug Administration in 1992 as a treatment of major depressive disorder.

Sertraline uses

Currently, sertraline is approved by the FDA to treat major depressive disorder (MDD), as well as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. Not all mental health conditions can be treated by a provider through our platform.

How sertraline works

Sertraline (generic for Zoloft®) works by controlling the amount of serotonin that is reabsorbed by neurons in the brain, which increases the amount of free serotonin in the brain. For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

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Generic for Zoloft®

How to get sertraline online with Hims

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get sertraline shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

Sertraline 101

What’s an SSRI?

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that work by increasing levels of a mood-affecting chemical called serotonin in the brain which helps to improve your symptoms. Nice, right?

The science of sertraline

Your brain naturally produces chemicals that make you feel good, like serotonin. Sertraline keeps neurons from reabsorbing this chemical so that you have more of it available in your brain. Long story short? For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.

Felt better

Over 75% of Hims customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hims customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hims platform; and 3) had an active subscription for such antidepressant medication through the Hims platform within 90 days after signing up.

You’re in good hands

Before they're accepted to the pool of professionals we work with, all healthcare providers undergo a rigorous vetting process. They have years of experience and they’re ready to help with whatever you’re going through.

Frequently asked questions about sertraline

How long does it take for sertraline (generic for Zoloft) to work?

Sertraline was shown to be effective as a treatment for major depressive disorder and other anxiety-related disorders in clinical trials lasting 6-12 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

What drugs interact with sertraline?

Interactions between sertraline and other substances can occur. Interaction risks include but are not limited to: MAO inhibitor (MAOI) drugs (eg, linezolid, methylene blue, etc), other antidepressant medication ( that can cause a rare but serious condition known as serotonin syndrome), nsaids (eg, naproxen, ibuprofen), the drug pimozide, certain recreational drugs including alcohol and the herbal supplement St. John's Wort. Be prepared to share all prescription and over-the-counter medications, as well as any other products you take, with your healthcare provider to avoid any adverse effects.
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. Talk to your provider about common and less common but serious side effects, potential allergic reactions, and any other questions you may have.

How does sertraline (generic for Zoloft) make you feel?

Sertraline has been shown to be effective in treating symptoms of depression and anxiety. Even if you start to feel better, do not stop taking your medication without first talking to your healthcare provider.

What other drugs are SSRIs like sertraline?

Other SSRIs include fluoxetine (generic for Prozac), citalopram (generic for Celexa), and paroxetine.

How is sertraline used “off-label”?

Off-label prescription use is the use of drugs outside of the approved age range, dosing, or typical administering. Some conditions that sertraline is prescribed as an off-label treatment for are:

Is there a pediatric dose of sertraline?

Sertraline is FDA approved for young adults and children under the age of 18 who have OCD.

How do I buy sertraline online?

Consult with a psychiatrist or other qualified psychiatry provider online through our platform. If you are prescribed sertraline, genuine sertraline hydrochloride (HCl) will be shipped to you discreetly. You’ll have ongoing check-ins with a healthcare provider to evaluate whether your treatment plan is working.

Learn more about sertraline

Important safety information

Learn more about sertraline

Important safety information


If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.


If you’re having a medical or mental health emergency, call 911 or go to your local ER.

More for your mind

Sertraline (Zoloft) 101

Top 25 Sertraline Questions Answered

* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.