FDA approved

Generic for Zoloft®Sertraline

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been simpler. Consult with a licensed healthcare provider to determine whether a medication like sertraline could be right for you.



Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate


Unlimited provider messaging


Unlimited dosage adjustments

What is sertraline?

Sertraline is a prescription drug and was one of the first SSRI (selective serotonin reuptake inhibitor) antidepressants on the US market. Sertraline is marketed under the brand name Zoloft®, which was first approved by the Food and Drug Administration in 1992 as a treatment of major depressive disorder.

Sertraline uses

Currently, sertraline is approved by the FDA to treat major depressive disorder (MDD), as well as obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. Not all mental health conditions can be treated by a provider through our platform.

How sertraline works

Sertraline (generic for Zoloft®) works by controlling the amount of serotonin that is reabsorbed by neurons in the brain, which increases the amount of free serotonin in the brain. For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.

* Only available if prescribed after an online consultation with a healthcare provider.

* Controlled substances such as Xanax and Adderall are not available through our platform.

* This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

Select your plan

try it out

Generic for Zoloft®

How to get sertraline online with Hims

1. Simple consultation

Complete an online mental health assessment and intake form, then connect with a healthcare provider through our platform.

2. Free delivery

Get sertraline shipped to you for free, if prescribed.

3. Ongoing support

Enjoy secure, ongoing support 100% online—including refills and unlimited dosage adjustments.

Sertraline 101

What’s an SSRI?

Selective serotonin reuptake inhibitors (SSRIs) are a type of antidepressant that work by increasing levels of a mood-affecting chemical called serotonin in the brain which helps to improve your symptoms. Nice, right?

The science of sertraline

Your brain naturally produces chemicals that make you feel good, like serotonin. Sertraline keeps neurons from reabsorbing this chemical so that you have more of it available in your brain. Long story short? For people with depression and anxiety disorders, this can help to improve their interest in activities or reduce their number of panic attacks.

Featured reviews

Real results from guys like you


“Without Hims, I do not think that I would have been able to manage such a stressful period of my life without having access to my needed medication.”

Verified review


“Signing up for the session was easy, it was free, private and totally online. I couldn’t have gotten a better set up.”

Verified review


“It’s tough during these times and I definitely felt like I had a team helping me out. I needed this and I know others will too.”

Verified review


“During the pandemic, gaining access to a doctor was made more difficult and Hims was the solution I found to address my need for mental health care.”

Verified review


“So far, I have loved the experience with HIMS and I am noticing a positive effect from the medication I have been taking.”

Verified review

These customers’ results have not been independently verified. Individual results will vary. Customers were given free product.

Felt better

Over 75% of Hims customers who checked in with their provider reported improvements in their mental health symptoms.*

* Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hims customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hims platform; and 3) had an active subscription for such antidepressant medication through the Hims platform within 90 days after signing up.

You’re in good hands

Before they're accepted to the pool of professionals we work with, all healthcare providers undergo a rigorous vetting process. They have years of experience and they’re ready to help with whatever you’re going through.

Frequently asked questions about sertraline

How long does it take for sertraline (generic for Zoloft) to work?

Sertraline was shown to be effective as a treatment for major depressive disorder and other anxiety-related disorders in clinical trials lasting 6-12 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

What drugs interact with sertraline?

Interactions between sertraline and other substances can occur. Interaction risks include but are not limited to: MAO inhibitor (MAOI) drugs (eg, linezolid, methylene blue, etc), other antidepressant medication ( that can cause a rare but serious condition known as serotonin syndrome), nsaids (eg, naproxen, ibuprofen), the drug pimozide, certain recreational drugs including alcohol and the herbal supplement St. John's Wort. Be prepared to share all prescription and over-the-counter medications, as well as any other products you take, with your healthcare provider to avoid any adverse effects.
Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. Talk to your provider about common and less common but serious side effects, potential allergic reactions, and any other questions you may have.

How does sertraline (generic for Zoloft) make you feel?

Sertraline has been shown to be effective in treating symptoms of depression and anxiety. Even if you start to feel better, do not stop taking your medication without first talking to your healthcare provider.

What other drugs are SSRIs like sertraline?

Other SSRIs include fluoxetine (generic for Prozac), citalopram (generic for Celexa), and paroxetine.

How is sertraline used “off-label”?

Off-label prescription use is the use of drugs outside of the approved age range, dosing, or typical administering. Some conditions that sertraline is prescribed as an off-label treatment for are:

Is there a pediatric dose of sertraline?

Sertraline is FDA approved for young adults and children under the age of 18 who have OCD.

How do I buy sertraline online?

Consult with a psychiatrist or other qualified psychiatry provider online through our platform. If you are prescribed sertraline, genuine sertraline hydrochloride (HCl) will be shipped to you discreetly. You’ll have ongoing check-ins with a healthcare provider to evaluate whether your treatment plan is working.

Learn more about sertraline

Important safety information

Learn more about sertraline

Important safety information

Important Safety Information

Do not take Sertraline if you:
  • are allergic to Sertraline, or any of the ingredients in Sertraline
  • take any medicines called monoamine oxidase inhibitor (MAOI), or if you have stopped taking an MAOI within the last 2 weeks
  • taking pimozide
  • are drinking alcohol
  • are using or abusing recreation drugs or prescription medications
Sertraline can cause serious side effects. Rarely reported side effects include:
  • low sodium blood levels (symptoms may include headache, weakness and difficulty remembering or concentrating)
  • teeth grinding
  • angle closure glaucoma (symptoms of angle closure glaucoma may include eye pain, changes in vision, swelling or redness in or around eye)
  • serotonin syndrome (symptoms may include shivering, diarrhea, confusion, severe muscle tightness, fever, seizures, and death)
  • seizure
  • increased risk of bleeding events when combined with use of aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen), warfarin, and other anticoagulants
Before you take Sertraline, tell your healthcare provider if you:
  • have thoughts of suicide or harming yourself
  • have a history of psychiatric or medical problems, including bipolar disorder
  • have taken any medication in the past for your condition, whether effective or not
  • have suffered adverse or side effects from previous medication therapies
  • are receiving any non-medication treatment, such as talk therapy
  • drink alcohol or use/abuse recreational or prescription drugs
  • are pregnant, plan to become pregnant, or are breastfeeding
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, herbal supplements, and recreational drugs.
Sertraline may affect the way other medicines work, and other medicines may affect the way Sertraline works, causing side effects. Especially tell your healthcare provider if you take any of the following:
  • any other serotonergic medications, migraine medications (triptans), pain medications, antibiotic linezolid
  • aspirin, nonsteroidal anti-inflammatory drugs (e.g. ibuprofen, naproxen), warfarin, and other anticoagulants
  • disulfiram due to the alcohol content of the concentrate - if sertraline in liquid form
During treatment with this medication, the side effects of this medication may go away over the first week or two as your body adjusts to the medication. The most common side effects of Sertraline: Headache, nausea, diarrhea, dry mouth, increased sweating, feeling nervous, restless, fatigued, sleepy or having trouble sleeping (insomnia). Sexual side effects, such as problems with orgasm or ejaculatory delay often do not diminish over time.
Sertraline is a prescription medicine used to treat major depressive disorder (MDD), posttraumatic stress disorder (PTSD), premenstrual dysphoric disorder (PMDD), panic disorder, and social anxiety disorder. (May also be helpful when prescribed “off-label” for binge-eating disorder, bulimia nervosa, and generalized anxiety disorder (GAD).)
If you miss a dose of sertraline, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed.
Do not stop taking sertraline, even when you feel better. Abruptly stopping can cause withdrawal symptoms including: irritability, nausea, feeling dizzy, vomiting, nightmares, headache, and/or paresthesias (prickling, tingling sensation on the skin).
Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Patients, their families, and caregivers should be alert to the emergence of anxiety, restlessness, irritability, aggressiveness and insomnia. If these symptoms emerge, they should be reported to the patient’s prescriber or healthcare professional. All patients being treated with antidepressants for any indication should watch for and notify their healthcare provider for worsening symptoms, suicidality and unusual changes in behavior, especially during the first few months of treatment.
If needed, the best way to dispose of most types of old, unused, unwanted, or expired medicines (both prescription and over the counter) is to drop off the medicine at a drug take back site, location, or program immediately. You can use the DEA DIVERSION CONTROL DIVISION LOOKUP to find your nearest drug disposal site.
If you no longer need your medication, locations, or programs are available in your area, and there are no specific disposal instructions (such as flushing) in the medication guide or package insert, you can follow these simple steps to dispose of most medicines in your trash at home:
  • Mix medicines (liquid or pills; do not crush tablets or capsules) with an unappealing substance such as dirt, cat litter, or used coffee grounds;
  • Place the mixture in a container such as a sealed plastic bag;
  • Throw away the container in your trash at home; and
  • Delete all personal information on the prescription label of empty medicine bottles or medicine packaging, then trash or recycle the empty bottle or packaging.

If you're in emotional distress, text HOME to 741-741 to connect with a Crisis Text Line counselor immediately.


If you’re having a medical or mental health emergency, call 911 or go to your local ER.

Mental health supplements

Activate your best self. For help getting your decompress on and experiencing your best rest try our mental health wellness supplements.

Mind Unwind

An all-natural way to wind down at the end of a long day or just keep yourself in balance

Additional fees may apply

Sleep Tight Gummies

A delicious dose of snooze to help you go from counting sheep to getting Zzzzs

Additional fees may apply

More for your mind

Sertraline (Zoloft) 101

Top 25 Sertraline Questions Answered

* Controlled substances, including amphetamines (such as Adderall) or benzodiazepines (such as Xanax and Valium) are not available through our platform.