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Sildenafil Vs. Viagra: Drug Comparison

Compare common side effects, interactions, warnings, and more.

Medical Review byMike Bohl, MD, MBA, MPH, MS, ALMNov 4, 2024

Medication Name

Summary

Prescription only

Sildenafil is the active ingredient in the brand-name medication Viagra®. The information below is about brand name Viagra. According to the FDA, “Generic medicines use the same active ingredients as brand-name medicines and work the same way, so they have the same risks and benefits as the brand-name medicines.”

Viagra (sildenafil citrate), a phosphodiesterase type 5 (PDE5) inhibitor, is an oral medication used to treat erectile dysfunction (ED). It is taken only as needed, usually about an hour before sexual activity, though it can be effective if taken between 30 minutes to 4 hours prior. It is very important not to take Viagra more than once a day, as exceeding this frequency increases the risk of serious side effects, including vision loss and significant drops in blood pressure.

Prescription only

Viagra® (sildenafil citrate), a phosphodiesterase type 5 (PDE5) inhibitor, is an oral medication used to treat erectile dysfunction (ED). It is taken only as needed, usually about an hour before sexual activity, though it can be effective if taken between 30 minutes to 4 hours prior. It is very important not to take Viagra more than once a day, as exceeding this frequency increases the risk of serious side effects, including vision loss and significant drops in blood pressure.

ED Treatment

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Drug Category

Phosphodiesterase-5 (PDE5) inhibitor

Phosphodiesterase-5 (PDE5) inhibitor

Approved Uses

Viagra (sildenafil citrate) is indicated to treat:

  • Erectile dysfunction (ED)

Viagra (sildenafil citrate) is indicated to treat:

  • Erectile dysfunction (ED)

ED Treatment

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Dosage

  • Typically taken orally as needed approximately 60 minutes before sexual activity, up to once daily

  • Comes in 25 mg, 50 mg, and 100 mg tablets

  • Typically taken orally as needed approximately 60 minutes before sexual activity, up to once daily

  • Comes in 25 mg, 50 mg, and 100 mg tablets

Known Common Side Effects

Most common adverse reactions (≥2%) include:

  • Headache

  • Flushing

  • Indigestion

  • Abnormal vision

  • Nasal congestion

  • Back pain

  • Muscle pain

  • Nausea

  • Dizziness

  • Rash

Most common adverse reactions (≥2%) include:

  • Headache

  • Flushing

  • Indigestion

  • Abnormal vision

  • Nasal congestion

  • Back pain

  • Muscle pain

  • Nausea

  • Dizziness

  • Rash

Interactions & Contraindications

  • Administration of Viagra to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form

  • Known hypersensitivity to sildenafil or any component of tablet

  • Drug interactions: Nitrates, alpha blockers, antihypertensives, CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, saquinavir, erythromycin)

  • Administration of Viagra to patients using nitric oxide donors, such as organic nitrates or organic nitrites in any form

  • Known hypersensitivity to sildenafil or any component of tablet

  • Drug interactions: Nitrates, alpha blockers, antihypertensives, CYP3A4 inhibitors (e.g., ritonavir, ketoconazole, itraconazole, saquinavir, erythromycin)

Warnings & Precautions

  • Patients should not use Viagra if sexual activity is inadvisable due to cardiovascular status

  • Patients should seek emergency treatment if an erection lasts >4 hours

  • Patients should stop Viagra and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non arteritic anterior ischemic optic neuropathy (NAION)

  • Patients should stop Viagra and seek prompt medical attention in the event of sudden decrease or loss of hearing

  • Caution is advised when Viagra is co-administered with alpha-blockers or anti-hypertensives

  • Decreased blood pressure, fainting, and prolonged erection may occur at higher sildenafil exposures

  • Patients should not use Viagra if sexual activity is inadvisable due to cardiovascular status

  • Patients should seek emergency treatment if an erection lasts >4 hours

  • Patients should stop Viagra and seek medical care if a sudden loss of vision occurs in one or both eyes, which could be a sign of non arteritic anterior ischemic optic neuropathy (NAION)

  • Patients should stop Viagra and seek prompt medical attention in the event of sudden decrease or loss of hearing

  • Caution is advised when Viagra is co-administered with alpha-blockers or anti-hypertensives

  • Decreased blood pressure, fainting, and prolonged erection may occur at higher sildenafil exposures

ED Treatment

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References

*This information is from the label for brand name Viagra®. See the Full Prescribing Information for more complete information. Sildenafil, the active ingredient in Viagra, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient sildenafil.

*This information is from the label for brand name Viagra®. See the Full Prescribing Information for more complete information. Sildenafil, the active ingredient in Viagra, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient sildenafil.

The information provided here is NOT MEDICAL ADVICE and is for informational and educational purposes only. The drug comparison tool does not determine eligibility for medications or treatments provided via the Hims/Hers platform. Consultation with a healthcare provider is required to assess suitability for any medical treatment based on individual health and medical history. All product names and associated trademarks are the property of their respective owners.

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