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Does Lisinopril Cause ED?

Kelly Brown MD, MBA

Reviewed by Kelly Brown MD, MBA

Written by Nicholas Gibson

Published 06/15/2021

Updated 03/08/2024

Erectile dysfunction, or ED, is one of the most common sexual performance issues for men, affecting approximately 30 million men in the United States alone.

Many causes of erectile dysfunction are related to physical or mental health issues. However, it’s also possible for ED to develop as a side effect of certain medications, including medications for cardiovascular health issues, like lisinopril. However, is there a link between lisinopril and ED?

  • Although some lisinopril users report experiencing erectile dysfunction during treatment, studies tend to show that ED isn’t a common side effect of this medication.

  • Lisinopril is a high blood pressure medication that may improve erectile dysfunction symptoms.

Does Lisinopril Cause ED? The Connection Between High Blood Pressure and Erectile Dysfunction

Lisinopril is a medication used to treat hypertension, or high blood pressure. It belongs to a class of medications called angiotensin-converting enzyme (ACE) inhibitors and is sold under a variety of brand names, including Zestril® and Prinivil®.

As an ACE inhibitor, lisinopril works by reducing the amount of certain types of vasoconstrictive hormones in your body. These hormones constrict your blood vessels and may increase blood pressure, putting extra stress on your organs and blood vessels. 

By relaxing your blood vessels, medications like lisinopril can reduce blood pressure and make blood flow throughout your body easier. Your healthcare provider might prescribe you lisinopril if you’ve been diagnosed with high blood pressure, a common condition that can affect men of all ages and backgrounds. 

Other situations in which you may be prescribed lisinopril include during recovery from a heart attack or if you have been diagnosed with heart failure or heart disease. 

In certain cases, lisinopril and related medications are also used to treat kidney issues such as renal impairment, according to an article published by the NIH. Lisinopril is available as a tablet and as a liquid solution. It’s typically prescribed for use once a day. 

If you’re prescribed this medication, it’s important to closely follow the dosage instructions provided by your healthcare provider. 

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Erectile dysfunction and other sexual performance issues are not listed as common side effects of lisinopril. 

However, some research has found that lisinopril may temporarily cause sexual side effects during the first few months of treatment. 

For example, a study published in the American Journal of Hypertension compared the effects of lisinopril and the beta-blocker atenolol on erectile function in a group of  90 men with high blood pressure aged 40 to 49.

The researchers found that both drugs seemed to reduce sexual activity in the short term, but that the men who used lisinopril returned to their normal levels of sexual activity over the long term.

In total, 17 percent of the men prescribed atenolol experienced sexual dysfunction symptoms, compared to just three percent of the men prescribed lisinopril.

In short, you may experience ED or other sexual issues when you first start using lisinopril, but research suggests that this isn’t a long-term issue.

In general, angiotensin-converting enzyme (ACE) inhibitors — the class of medications to which lisinopril belongs — are among the cardiovascular medications least likely to cause ED, according to an article published in the book, StatPearls.

Other Lisinopril Side Effects in Men

Like other medications, lisinopril can potentially cause side effects. According to FDA data, the most common side effects of lisinopril include headache, dizziness, cough, hyperkalemia (high potassium levels), hypotension (low blood pressure) and syncope (passing out).

Some of these side effects may be more common if you’re prescribed lisinopril for heart failure or during recovery after a heart attack.

Hypertension, or high blood pressure, is a common cause of erectile dysfunction. In one study published in the Indian Journal of Urology, researchers found that 58.3 percent of hypertensive men reported experiencing erectile dysfunction.

Other research published in the journal, Vascular Health and Risk Management, has found that the incidence of erectile dysfunction is closely related to high blood pressure. 

Although the link between lisinopril and erectile dysfunction is mild, other medications for high blood pressure can cause ED. For example, many thiazide diuretics and sympathetic blocking agents are known to cause erectile dysfunction as a side effect.

Choose your chew

Several other ACE inhibitors are commonly prescribed to treat high blood pressure and other heart health issues. 

These include benazepril (Lotensin®), enalapril (Vasotec®), candesartan (Atacand®), fosinopril (Monopril®) and others.

In general, erectile dysfunction is rarely a side effect of ACE inhibitors, according to an article published by Harvard Health. Other medications for high blood pressure, including alpha-blockers and angiotensin II receptor blockers (ARBs), also rarely contribute to ED.

Currently, the most effective treatments for erectile dysfunction arePDE5 inhibitor medications, such as sildenafil (the active ingredient in Viagra®),tadalafil (Cialis®), vardenafil (Levitra®) and avanafil (Stendra®).

These medications work by increasing the rate of blood flow to the erectile tissue of your penis, making it easier to get and maintain an erection when you’re sexually aroused. 

Because PDE5 inhibitors and anti-hypertensive medications both improve blood flow and lower blood pressure, there’s a risk of interactions when ED medications are used with some common medications for high blood pressure. 

For example, many medications for ED can interact with organic nitrates and nitrites, as well as alpha-blockers used to treat high blood pressure and/or heart failure, according to the FDA

Our guide to Viagra and nitrates provides more information on these interactions and their often severe health risks.

Research published in the American Journal of Hypertension suggests that ACE inhibitors such as lisinopril, on the other hand, do not increase the risk of side effects with ED medications such as sildenafil.

If you currently use lisinopril or other medication to control your blood pressure, it’s important to inform your healthcare provider about this before using any ED medications.

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Although some high blood pressure meds can cause ED, most data shows that lisinopril doesn’t cause any long-term sexual performance issues. 

If you’re prescribed lisinopril and find it hard to get or maintain an erection, making changes to your lifestyle and using ED medication may help to improve your sexual function and allow you to enjoy a fulfilling, satisfying sex life. 

To avoid interactions, it’s important to seek medical advice by informing your healthcare provider about all medications and supplements you currently take before using sildenafil or similar medications to treat ED.

18 Sources

  1. Definition & Facts for Erectile Dysfunction. (2017, July). Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/definition-facts
  2. Lisinopril. (2021, February 15). Retrieved from https://medlineplus.gov/druginfo/meds/a692051.html
  3. LABEL: PRINIVIL- lisinopril tablet. (2020, December 23). Retrieved from https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f6f3c339-2c9d-4d07-14a1-6d6c7daf26c6
  4. Erection Ejaculation: How It Occurs. (2020, November 27). Retrieved from https://my.clevelandclinic.org/health/articles/10036-erection-ejaculation-how-it-occurs
  5. Symptoms & Causes of Erectile Dysfunction. (2017, July). Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/symptoms-causes
  6. Zestril® (lisinopril) tablets, for oral use. (2014, December). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019777s064lbl.pdf
  7. Fogari, R., et al. (1998, October). Sexual Function in Hypertensive Males Treated with Lisinopril or Atenolol: A Cross-Over Study. American Journal of Hypertension. 11 (10), 1244–1247. Retrieved from https://academic.oup.com/ajh/article/11/10/1244/163252
  8. Sooriyamoorthy, T. & Leslie, S.W. (2021, April 4). Erectile Dysfunction. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK562253/
  9. Afifi, et al. (2007, April-June). Erectile dysfunction among hypertensive men in a rapidly developing country. Indian Journal of Urology. 23 (2), 109–113. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721515/
  10. Bertomeu-González, et al. (2020). Understanding Erectile Dysfunction in Hypertensive Patients: The Need for Good Patient Management. Vascular Health and Risk Management. 16, 231–239. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297457
  11. VIAGRA® (sildenafil citrate) tablets, for oral use. (2014, March). Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/20895s039s042lbl.pdf
  12. Brown, et al. (2001, January). Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. American Journal of Hypertension. 14 (1), 70–73. Retrieved from https://academic.oup.com/ajh/article/14/1/70/135977
  13. Agbanusi, et al. (2011, November). Effects of Aerobic Exercise in the Management of Erectile Dysfunction: A Meta Analysis Study on Randomized Controlled Trials. Ethiopian Journal of Health Science. 21 (3), 195–201. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3275865/
  14. Carpio-Rivera, et al. (2016, May). Acute Effects of Exercise on Blood Pressure: A Meta-Analytic Investigation. Arquivos Brasileiros de Cardiologia. 106 (5), 422–433. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4914008/
  15. Esposito, et al. (2010, July). Dietary factors, Mediterranean diet and erectile dysfunction. The Journal of Sexual Medicine. 7 (7), 2338-45. Retrieved from https://pubmed.ncbi.nlm.nih.gov/20487239/
  16. De Pergola, G. & D’Alessandro, A. (2018, November). Influence of Mediterranean Diet on Blood Pressure. Nutrients. 10 (11), 1700. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266047/
  17. Harte, C.B. & Meston, C.M. (2008, January). Acute Effects of Nicotine on Physiological and Subjective Sexual Arousal in Nonsmoking Men: A Randomized, Double-Blind, Placebo-Controlled Trial. The Journal of Sexual Medicine. 5 (1), 110–121. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2864030/
  18. Blood pressure drugs and Ed: What you need to know. Harvard Health. (2017, May 30). Retrieved January 17, 2023, from https://www.health.harvard.edu/mens-health/blood-pressure-drugs-and-ed-what-you-need-to-know
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Kelly Brown MD, MBA
Kelly Brown MD, MBA

Dr. Kelly Brown is a board certified Urologist and fellowship trained in Andrology. She is an accomplished men’s health expert with a robust background in healthcare innovation, clinical medicine, and academic research. Dr. Brown is a founding member of Posterity Health where she is Medical Director and leads strategy and design of their Digital Health Platform, an innovative education and telehealth model for delivering expert male fertility care.

She completed her undergraduate studies at University of North Carolina at Chapel Hill (go Heels!) with a Bachelor of Science in Radiologic Science and a Minor in Chemistry. She took a position at University of California Los Angeles as a radiologic technologist in the department of Interventional Cardiology, further solidifying her passion for medicine. She also pursued the unique opportunity to lead departmental design and operational development at the Ronald Reagan UCLA Medical Center, sparking her passion for the business of healthcare.

Dr. Brown then went on to obtain her doctorate in medicine from the prestigious Northwestern University - Feinberg School of Medicine and Masters in Business Administration from Northwestern University - Kellogg School of Management, with a concentration in Healthcare Management. During her surgical residency in Urology at University of California San Francisco, she utilized her research year to focus on innovations in telemedicine and then served as chief resident with significant contributions to clinical quality improvement. Dr. Brown then completed her Andrology Fellowship at Medical College of Wisconsin, furthering her expertise in male fertility, microsurgery, and sexual function.

Her dedication to caring for patients with compassion, understanding, as well as a unique ability to make guys instantly comfortable discussing anything from sex to sperm makes her a renowned clinician. In addition, her passion for innovation in healthcare combined with her business acumen makes her a formidable leader in the field of men’s health.

Dr. Brown is an avid adventurer; summiting Mount Kilimanjaro in Tanzania (twice!) and hiking the incredible Torres del Paine Trek in Patagonia, Chile. She deeply appreciates new challenges and diverse cultures on her travels. She lives in Denver with her husband, two children, and beloved Bernese Mountain Dog. You can find Dr. Brown on LinkedIn for more information.

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