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Should You Take Daily ED Medication?

Mike Bohl, MD, MBA, MPH, MS, ALM

Reviewed by Mike Bohl, MD

Written by Erica Garza

Published 03/13/2025

The most popular erectile dysfunction (ED) medications are phosphodiesterase type 5 enzyme (PDE5) inhibitors like Viagra® (sildenafil). You typically take them as needed before sex. 

But if waiting 30 minutes to an hour for a pill to kick in feels like a mood-killer, a daily option like Cialis® (tadalafil) might be a better fit to treat erectile dysfunction.

Taking ED medication daily allows for more spontaneity, but not all ED meds are approved for daily use. Only certain medications at specific doses are approved for this purpose.

Below, we break down which ED medications work for daily use and how to take them to support a more spontaneous sex life.

Yes, you can absolutely take certain types of ED medication daily. Doctors regularly prescribe brand name Cialis and generic tadalafil for safe daily use.

Cialis’s active ingredient, tadalafil (which can also help treat an enlarged prostate or benign prostatic hyperplasia), is an ED medication that you can take daily at lower doses

While Viagra, Levitra (vardenafil), and Stendra (avanafil) are proven on-demand ED meds, Cialis is effective for both daily and as-needed use. 

Many placebo-controlled and randomized studies over the years have shown that daily tadalafil is an effective treatment for ED.

We already mentioned that daily Cialis accommodates more spontaneous sex, but what does that mean exactly? 

If planning your intimate moments feels like a hassle, daily ED medication could be a welcome solution. It gives you the flexibility to be ready anytime the moment’s right. And that’s not the only benefit. 

Some research shows that daily tadalafil may also work as a short-term treatment for men with ED. According to one 2024 study involving 96 ED participants under 50 years of age, 5 mg daily tadalafil helped 82 of them (85.4 percent) achieve full erectile function recovery after stopping tadalafil following three months of treatment. 

But, the men in the study were all seeking help for psychogenic ED (AKA psychological ED). It’s not clear whether the results would be the same for men over 50 with ED due to physical causes. 

Daily tadalafil may also help with other medical issues like lower urinary tract symptoms associated with benign prostatic hyperplasia and cardiovascular issues in men with or without erectile dysfunction.

We’ll cover the potential side effects later, but here’s something worth noting: taking tadalafil daily often leads to fewer side effects than as-needed ED meds. Why? The daily dose is lower. 

Want more spontaneous sex without needing to plan ahead? Daily Cialis might be the right ED medication for you.

The FDA-approved starting dose for daily Cialis or tadalafil is 2.5 milligrams, going up to 5 mg. Many urologists and sexual medicine experts start people on 5 mg per day and adjust up or down as needed to achieve the best results. 

Even though the 10 milligrams per day dose is an off-label use — meaning it’s not approved for daily use at that dose — high-quality clinical evidence shows it’s likely safe and effective. 

PDE5 inhibitors increase blood flow to your penis to make erections easier to achieve and maintain when you’re aroused. You can usually take them at any time of day. 

But if you’re taking a PDE5 inhibitor like Cialis daily, a healthcare professional might recommend:

  • Taking it at the same time each day.

  • Not taking two days’ worth of medication in a single day.

  • Taking it with a meal

  • Avoiding taking it alongside grapefruit, which may increase blood levels

  • Avoiding taking it with fatty foods, which may slow absorption and reduce effectiveness

Taking Cialis daily is generally safe when taken at the dose your doctor prescribes. It may even lower your risk of side effects compared to taking it only as needed. 

But, side effects can still happen, so it’s important to consult a healthcare professional before starting this medication. Let them know about any health conditions, like a history of heart attack or pulmonary arterial hypertension (AKA high blood pressure in the lungs).

Common side effects of Cialis and similar medications include:

  • Muscle aches

  • Nasal congestion

  • Indigestion

  • Muscle pain

  • Back pain

  • Fatigue

Rare but serious side effects can include hearing issues and priapism (a prolonged, painful erection requiring emergency care).

Additionally, some medications — like nitrates or alpha-blockers — can increase your risk of sudden low blood pressure when you combine them with Cialis. If you’re on any heart disease or blood pressure medications, let your doctor know. 

Always follow your doctor’s prescription and never take any ED medication without medical guidance. 

Non-prescription ED treatments, like dietary supplements or gas station sex pills, don’t measure up to FDA-approved medications like PDE5 inhibitors. These prescription options are proven safe and effective for millions of men. 

But not every treatment works the same for everyone. Some men can benefit from daily medications like Cialis, while others prefer on-demand options like sildenafil citrate.

That’s why it’s important to only take medication as prescribed and follow up with your healthcare provider to discuss your progress. 

And don’t worry, these meds only work with sexual stimulation, so you won’t get surprise erections at awkward moments. 

It’s also important to know that erectile dysfunction can stem from various causes like high blood pressure or psychological issues including:

Figuring out the root cause of your ED symptoms is the best way to find a solution that works for you.

Reach out to a healthcare provider or urology specialist if you think you’re experiencing erectile dysfunction to find the treatment plan that serves your exact needs.

Daily ED medication can be a game changer for some men. But you can’t necessarily just take a daily dose of any ED med — only certain medications will work. 

Let’s recap what we know about daily ED pills:

  • Cialis is an FDA-approved medication for the treatment of ED (and BPH, under the name Adcirca®). Healthcare professionals commonly prescribe it as a daily ED treatment.

  • A daily dose will be smaller. Daily doses range from 2.5 mg to 5 mg for most men.

  • There are many benefits to taking a daily ED medication. They include more spontaneous sex, a lower risk of medication side effects, and heart health benefits.

Daily tadalafil is an effective option for many men with ED, but don’t try to create your own daily routine. Speak with a healthcare professional to get the right medication and dosage for your needs.

We can help connect you with a provider who can prescribe ED medication if they think it’s appropriate. Take our assessment to get started!

11 Sources

  1. Cialis- tadalafil tablet, film coated. (2017). https://www.accessdata.fda.gov/spl/data/05dbd8b6-1b9d-436a-a67c-8a16713f753f/05dbd8b6-1b9d-436a-a67c-8a16713f753f.xml
  2. CIALIS (tadalafil) tablets, for oral use. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021368s20s21lbl.pdf
  3. Dhaliwal, A. & Gupta, M. (2022). PDE5 Inhibitors. https://www.ncbi.nlm.nih.gov/books/NBK549843/
  4. Frajese GI, et al. (2006). Tadalafil in the treatment of erectile dysfunction: An overview of the clinical evidence. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2699638/
  5. Goberdhan SA, et al. (2022). Is tadalafil associated with decreased risk of major adverse cardiac events or venous thromboembolism in men with lower urinary tract symptoms?. https://pmc.ncbi.nlm.nih.gov/articles/PMC9037966/
  6. Hatzimouratidis KO, et al. (2014). A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction. https://pmc.ncbi.nlm.nih.gov/articles/PMC4054509/
  7. Marumo, K., et al. (2007). A comparison of the efficacy and tolerability of tadalafil 10 mg and 20 mg in Japanese patients with severe erectile dysfunction. https://pubmed.ncbi.nlm.nih.gov/17087800/
  8. Pozzi ED, et al. (2024). Spontaneous erectile function recovery among young men with erectile dysfunction taking tadalafil 5 mg once a day. https://academic.oup.com/jsm/article/21/8/671/7695980?login=false
  9. Symptoms & causes of erectile dysfunction. (2017). https://www.niddk.nih.gov/health-information/urologic-diseases/erectile-dysfunction/symptoms-causes
  10. Washington SA, et al. (2010). A once-daily dose of tadalafil for erectile dysfunction: Compliance and efficacy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2939761
  11. Wright, D.F., et al. (2011). Understanding the time course of pharmacological effect: A PKPD approach. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099368/
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Mike Bohl, MD

Dr. Mike Bohl is a licensed physician, the Director of Medical Content & Authority at Hims & Hers, and a member of the Obesity Medicine Association. Prior to joining Hims & Hers, Dr. Bohl worked in digital health at Ro, focusing on patient education, and as the Director of Scientific & Medical Content at a stealth biotech PBC, working on pharmaceutical drug development. He has also worked in medical journalism for The Dr. Oz Show (receiving recognition for contributions from the National Academy of Television Arts and Sciences when the show won Outstanding Informative Talk Show at the 2016–2017 Daytime Emmy® Awards) and at Sharecare, and he is a Medical Expert Board Member at Eat This, Not That!.

Dr. Bohl obtained his Bachelor of Arts and Doctor of Medicine from Brown University, his Master of Business Administration and Master of Science in Healthcare Leadership from Cornell University, his Master of Public Health from Columbia University, and his Master of Liberal Arts in Extension Studies—Journalism from Harvard University. Dr. Bohl trained in internal medicine with a focus on community health at NYU Langone Health, and he has earned a Certificate of Advanced Education in Obesity Medicine from the Obesity Medicine Association.

Dr. Bohl is Certified in Public Health by the National Board of Public Health Examiners, Medical Writer Certified by the American Medical Writers Association, a certified Editor in the Life Sciences by the Board of Editors in the Life Sciences, a Certified Personal Trainer and Certified Nutrition Coach by the National Academy of Sports Medicine, and a Board Certified Medical Affairs Specialist by the Accreditation Council for Medical Affairs. He has graduate certificates in Digital Storytelling and Marketing Management & Digital Strategy from Harvard Extension School and certificates in Business Law and Corporate Governance from Cornell Law School.

In addition to his written work, Dr. Bohl has experience creating medical segments for radio and producing patient education videos. He has also spent time conducting orthopaedic and biomaterial research at Case Western Reserve University and University Hospitals of Cleveland and practicing clinically as a general practitioner on international medical aid projects with Medical Ministry International.

Dr. Bohl lives in Manhattan and enjoys biking, resistance training, sailing, scuba diving, skiing, tennis, and traveling. You can find Dr. Bohl on LinkedIn for more information.

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