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Beta-Sitosterol & Hair Loss: Does it Work?

Knox Beasley, MD

Reviewed by Knox Beasley, MD

Written by Rachel Sacks

Published 09/17/2017

Updated 07/26/2024

What if there were a supplement that could help treat hair loss, reduce cholesterol levels, and provide numerous other health benefits?

We’re talking about beta-sitosterol, a phytosterol that’s linked to improvements in health issues like cholesterol, benign prostatic hyperplasia (BPH, or enlarged prostate), heart disease, and more.

Like many other dietary supplements though, research on the effects of beta-sitosterol as a treatment is limited. 

Below, we’ve dug into the science to find out if beta-sitosterol works as a natural treatment for male pattern baldness, BPH, and other health conditions.

How does beta-siosterol for hair loss work?

Beta-sitosterol (β-sitosterol, or b-sitosterol) is a naturally occurring plant sterol that’s found in many common cooking ingredients and plant foods, including nuts, seeds, legumes, rice bran, wheat germ, soybeans, avocados, vegetable oils, and olive oil.  

Many other common health foods, like margarine, are fortified to contain beta-sitosterol, stigmasterol, campesterol, and related plant sterols. 

Although beta-sitosterol isn’t a medicine, it’s an important precursor that’s used to make certain types of medicine.

It’s also widely used as a dietary supplement. Supplements that contain beta-sitosterol are often marketed as natural products for strengthening the immune system, managing high cholesterol, and reducing the effects of asthma, bronchitis, and migraines.

Studies of beta-sitosterol have shown that it can improve some urologic symptoms in men with BPH as well as treat prostate cancer. However, the long-term safety and efficacy are not well known. 

Since BPH is caused by the effects of DHT, some hypothesize that beta-sitosterol could be a potentially effective substance for reducing DHT levels and treating hair loss in men from male pattern baldness. 

Before we get into the science behind beta-sitosterol, let’s look at the general health benefits of beta-sitosterol.

Beta-sitosterol supplements are widely available from health food stores and online. They tend to be marketed as dietary supplements to reduce the risk of heart disease, with products often promoted as natural options for reducing low-density lipoprotein (LDL cholesterol, or “bad” cholesterol).

Lower cholesterol levels

Although most research is small in scale, some studies have shown that diets high in phytosterols may reduce cholesterol absorption in the digestive system and reduce LDL levels. This may help to treat and prevent atherosclerosis -- a form of hardening of the arteries that are caused by elevated cholesterol levels.

But beta-sitosterol doesn't appear to raise “good” or high-density lipoprotein (HDL) cholesterol levels.

Treat some symptoms of BPH

Several clinical trials suggest that beta-sitosterol can improve some symptoms of benign prostatic hyperplasia, including  weak urine flow and other symptoms related to urination.

Reduce inflammation

Research has shown that beta-sitosterol has anti-inflammatory effects in certain types of tissue.

May have anticancer properties

Researchers have also looked into the effects of dietary phytosterols such as beta-sitosterol on cancer cell growth.

In one study, researchers found that beta-sitosterol may enhance the effects of the medication tamoxifen, which is used to treat breast cancer in women and men.

However, this research is still in its early stages and shouldn’t be viewed as firm evidence that beta-sitosterol has anticancer properties, or that it or other natural supplements are effective at treating cancer.

May reduce hair loss

Like with many other natural supplements that are promoted as hair loss treatments, there isn’t very much scientific evidence available for or against beta-sitosterol at this point.

The most common form of hair loss is male pattern baldness, which is caused by a mix of genetic factors and the effects of androgen hormones such as dihydrotestosterone (DHT).

As we mentioned above, a systematic review that looked at studies of beta-sitosterol found that it appears to improve urinary flow and other symptoms in men with prostate enlargement.

Like with male pattern baldness, experts believe that benign prostatic hyperplasia is caused by the effects of DHT, which can bind to receptors in the prostate and cause the tissue to continue growing with age.

Because DHT plays a major role in prostate enlargement and beta-sitosterol treats certain BPH symptoms, some supplement manufacturers have claimed that beta-sitosterol is a DHT blocker that’s effective at treating hair loss. 

Right now, there isn’t any large-scale research to support this claim. This means that it isn’t yet possible to say whether or not beta-sitosterol works as a hair loss treatment.

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Overall, beta-sitosterol appears to be safe, although, like other supplements, it can cause some adverse effects. 

Some men who use beta-sitosterol have reported digestion and stomach problems. Research also shows that beta-sitosterol can contribute to erectile dysfunction, although only a very small percentage of users (approximately half of one percent) report this side effect.

Beta-sitosterol and certain other plant sterols are also associated with sitosterolemia -- a health condition in which large quantities of plant sterols accumulate in the blood and tissue.

Sitosterolemia can cause some health issues, including an increased risk of stroke, heart attack, and other cardiovascular health events.

Sitosterolemia is very rare, with only 80 to 100 documented cases in the medical literature. It’s caused by genetic mutations that can affect your body’s ability to eliminate plant sterols. If you have sitosterolemia, you should not use beta-sitosterol supplements.

As a dietary supplement, beta-sitosterol hasn’t gone through the same testing process as drugs approved by the Food and Drug Administration.

To reduce your risk of side effects or interactions, make sure to inform your healthcare provider before using beta-sitosterol or any other dietary supplements. 

Your provider will be able to give you a more complete understanding of beta-sitosterol’s safety as part of your health and supplementation routine.

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Before/after images shared by customers who have purchased varying products, including prescription based products. Prescription products require an online consultation with a healthcare provider who will determine if a prescription is appropriate. These customers’ results have not been independently verified. Individual results will vary. Customers were given free product.

Beta-sitosterol is available over the counter as a dietary supplement, meaning you can access it from your local health store or purchase it online without any need for a prescription.

As a supplement, beta-sitosterol may have positive effects on cholesterol metabolism and blood lipid levels. 

It may also have anti-inflammatory and antioxidant properties that make it worth considering as a general health and well-being supplement. 

As for its value as a treatment for hair loss, the jury is still out. While beta-sitosterol’s effects on BPH symptoms and the data on hair growth are interesting, there isn’t enough evidence to call this an effective supplement for treating male pattern baldness yet.

Interestingly, the FDA-approved hair loss medication finasteride (sold as Propecia®) first came onto the market as a treatment for BPH.

In fact, finasteride is still prescribed today to stop prostate growth and manage BPH symptoms under the brand name Proscar®.

There is some scientific evidence that beta-sitosterol could potentially improve hair growth in men with signs of male pattern baldness.

In a small study published in the Journal of Alternative and Complementary Medicine in 2002, researchers looked at the effects of botanical substances such as beta-sitosterol and saw palmetto (another popular hair loss supplement) as a treatment for male pattern baldness.

The study found that 60 percent of the men who received the beta-sitosterol and saw palmetto supplement showed a positive response to treatment over four to six months.

However, it’s difficult to know if the participants’ results were caused by the saw palmetto, the beta-sitosterol, or the two active ingredients together. 

Due to the lack of high-quality scientific evidence, at the moment, it’s best to take any claims of beta-sitosterol improving hair loss or blocking DHT with a grain of salt.

Right now, it belongs in the "unknown" category as a natural supplement for hair loss that might work, but also might not work.

So, if beta-sitosterol isn’t an effective option for treating hair loss, what is? Currently, the most effective products for treating hair loss are the FDA-approved hair loss medications finasteride and minoxidil. 

Finasteride is an oral medication that works by blocking DHT production. Research shows that it’s capable of reducing DHT levels by more than 70 percent and producing a real, measurable increase in hair growth in balding men.

Minoxidil, on the other hand, is a topical medication that works by moving hair follicles into the anagen, or active growth, phase of the hair growth cycle. 

It also improves blood circulation in the scalp, which may improve hair growth.

Research suggests that finasteride and minoxidil are most effective when used together. In one study published in the journal Dermatologic Therapy, more than 94 percent of men with hair loss who used a combination of finasteride and minoxidil showed improvements in hair growth.

We offer finasteride and minoxidil online, with finasteride available following a consultation with a licensed healthcare provider who will determine if a prescription is appropriate.

In addition to finasteride and minoxidil, products such as hair loss prevention shampoo and hair growth vitamins can also play a role in treating and preventing hair loss.

Hair loss treatments, delivered

Beta-sitosterol is an interesting supplement that appears to offer real benefits, especially when it comes to cardiovascular health.

  • Beta-sitosterol is a naturally-occurring plant sterol and is found in many plant foods such as beans, nuts, seeds, olive oil, avocados, and more.

  • Beta-sitosterol is thought to have many health benefits including lowering cholesterol, treating hair loss, and preventing certain types of cancer such as prostate, breast, and colon cancer.

  • While there are several benefits of beta-sitosterol, many of these aren’t backed up by large studies or other amounts of research.

If you’re losing your hair, you’ll get the best results from science-based, FDA-approved hair loss treatments such as finasteride and minoxidil.

14 Sources

  1. Babu, S. & Jayaraman, S. (2020, November). An update on β-sitosterol: A potential herbal nutraceutical for diabetic management. Biomedicine & Pharmacotherapy. 131, 110702. Retrieved from https://www.sciencedirect.com/science/article/pii/S0753332220308957
  2. Beta-Sitosterol Plant Extract. (2020, September 23). Retrieved from https://www.uofmhealth.org/health-library/ug1904spec
  3. Wilt, T., et al. (2000). Beta-sitosterols for benign prostatic hyperplasia. The Cochrane Database of Systematic Reviews. (2), CD001043. Retrieved from https://pubmed.ncbi.nlm.nih.gov/10796740/
  4. Racette, S.B., et al. (2010, January). Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study. The American Journal of Clinical Nutrition. 91 (1), 32-38. Retrieved from https://academic.oup.com/ajcn/article/91/1/32/4597163
  5. Sun, Y., Gao, L., Hou, W. & Wu, J. (2020). β-Sitosterol Alleviates Inflammatory Response via Inhibiting the Activation of ERK/p38 and NF-κB Pathways in LPS-Exposed BV2 Cells. BioMed Research International. 7532306. Retrieved from https://www.hindawi.com/journals/bmri/2020/7532306/
  6. Awad, A.B., Barta, S.L., Fink, C.S. & Bradford, P.G. (2008, April). β-Sitosterol enhances tamoxifen effectiveness on breast cancer cells by affecting ceramide metabolism. Molecular Nutrition & Food Research. 52 (4), 419-426. Retrieved from https://onlinelibrary.wiley.com/doi/10.1002/mnfr.200700222
  7. Prostate Enlargement (Benign Prostatic Hyperplasia). (2014, September). Retrieved from https://www.niddk.nih.gov/health-information/urologic-diseases/prostate-problems/prostate-enlargement-benign-prostatic-hyperplasia
  8. Prager, N., Bickett, K., French, N. & Marcovici, G. (2002, April). A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. Journal of Alternative and Complementary Medicine. 8 (2), 143-52. Retrieved from https://pubmed.ncbi.nlm.nih.gov/12006122/
  9. Webber, R. (2006). Benign prostatic hyperplasia. BMJ Clinical Evidence. 1801. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907637/
  10. Sitosterolemia. (2020, August 18). Retrieved from https://medlineplus.gov/genetics/condition/sitosterolemia/
  11. Zito, P.M., Bistas, K.G. & Syed, K. (2021, March 27). Finasteride. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK513329/
  12. Kaufman, K.D., et al. (1998, October). Finasteride in the treatment of men with androgenetic alopecia. Finasteride Male Pattern Hair Loss Study Group. Journal of the American Academy of Dermatology. 39 (4 Pt 1), 578-89. Retrieved from https://pubmed.ncbi.nlm.nih.gov/9777765/
  13. Badri, T., Nessel, T.A. & Kumar, D.D. (2021, April 13). Minoxidil. StatPearls. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK482378/
  14. Hu, R., et al. (2015, September-October). Combined treatment with oral finasteride and topical minoxidil in male androgenetic alopecia: a randomized and comparative study in Chinese patients. Dermatologic Therapy. 303-308. Retrieved from https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.12246
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Knox Beasley, MD

Dr. Knox Beasley is a board certified dermatologist specializing in hair loss. He completed his undergraduate studies at the United States Military Academy at West Point, NY, and subsequently attended medical school at Tulane University School of Medicine in New Orleans, LA. 

Dr. Beasley first began doing telemedicine during his dermatology residency in 2013 with the military, helping to diagnose dermatologic conditions in soldiers all over the world. 

Dr. Beasley is board certified by the American Board of Dermatology, and is a Fellow of the American Academy of Dermatology.

Originally from Nashville, TN, Dr. Beasley currently lives in North Carolina and enjoys spending time outdoors (with sunscreen of course) with his wife and two children in his spare time. 

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