What Is Kyzatrex? All Your Questions Answered

Key Takeaways:

• Kyzatrex is an FDA-approved medication used for testosterone replacement therapy in adult men with medically confirmed low testosterone.

• Kyzatrex can restore testosterone to a normal range and potentially improve symptoms of low testosterone, such as low energy, reduced muscle mass, and decreased sex drive, when administered by a healthcare provider.

• Kyzatrex carries some risks, including increased blood pressure, blood clots, and prostate issues. Regular monitoring can help reduce complications.

• It’s important to take Kyzatrex exactly as prescribed.

Kyzatrex^® is a brand-name prescription medication that contains the active ingredient testosterone undecanoate. It’s prescribed as part of testosterone replacement therapy (TRT) in adult men who have low testosterone, a condition medically known as hypogonadism.

Testosterone is the main androgen or male sex hormone and plays many roles in your body, such as helping you:

• Build and maintain muscle

• Maintain your mood and focus

• Maintain your sex drive

Kyzatrex is a popular choice for TRT because it’s taken orally rather than being administered via injection. It still comes with some risks, so it’s important to monitor treatment regularly and take it only as prescribed.

Learn more about Kyzatrex, including when it’s prescribed, potential benefits, and who may make a good candidate for this testosterone replacement therapy.

Kyzatrex is a synthetic form of the hormone testosterone. Its main function is to supplement testosterone levels in men with low testosterone. Unlike some other medications, such as enclomiphene or human chorionic gonadotropin (HCG), it doesn’t increase your body’s natural production of testosterone but instead provides your body with a synthetic form that your body treats as the same.

Testosterone helps regulate many processes in the male body, and levels outside the normal range can lead to problems with almost every aspect of your health. Just a few of testosterone’s functions include maintenance of your:

• Muscle mass and strength

• Sex drive and erectile function

• Mood, energy levels, vitality, and sense of well-being

• Bone density

• Distribution of body fat

• Red blood cell production

One of the main benefits of Kyzatrex versus other forms of TRT is that it’s available in capsules taken by mouth. Many men find this easier than having to undergo regular injections.

For men with low testosterone, Kyzatrex and other forms of TRT can potentially help reverse the signs and symptoms of low testosterone. For instance, current research suggests it may help:

• Improve muscle mass and strength

• Aid bone density

• Increase red blood cell production

• Boost low sex drive and help with sexual dysfunction

• Improve blood vessel function

• Lift mood

How Much Does Kyzatrex Raise Testosterone Levels?

The primary goal of TRT is to replenish testosterone levels if they’re outside the normal range. Doctors can prescribe various amounts of Kyzatrex or other forms of TRT based on how low your testosterone levels are. 

It may take several tries to find the optimal dose for you. During your treatment, you’ll receive regular follow-ups to check if treatment is working or evaluate whether your dose needs to be changed. If your testosterone levels are still low, your healthcare provider may increase your dose. If your levels are too high, they may cut it back.

The American Urological Association considers your testosterone levels low if they dip below 300 mg/dL. Some labs use a lower cut-off, such as 250 mg/dL.

Kyzatrex comes in softgel capsules in doses of 100 mg, 150 mg, and 200 mg. The recommended starting dose is 200 mg orally twice daily with food, although your doctor may recommend a different dose based on your test results.

Clinical studies have consistently shown that oral testosterone undecanoate can help increase testosterone levels. For example, in a 2022 study, researchers reported that more than 87 percent of men taking oral testosterone undecanoate achieved normal testosterone levels. 

All TRT medications require careful monitoring and regular follow-ups with your healthcare provider because of the risk of complications. 

Some of the more common and mild side effects reported with Kyzatrex include:

• Increased blood pressure (hypertension), which is the most frequently reported side effect, occurring in more than 2 percent of people

• Headaches

• Increased heart rate

• Increased prostate-specific antigen (PSA) levels

The Kyzatrex label also contains a black box warning, the strongest type of warning the FDA administers for prescription drugs, that lists the following concerns:

• Kyzatrex can increase blood pressure, which can increase the risk of cardiovascular events, such as heart attack or stroke.

• Before doctors prescribe Kyzatrex, it’s essential to ensure blood pressure is adequately controlled.

• Periodic monitoring for new high blood pressure is essential to continuously ensure the benefits outweigh the risks.

• Due to the risk of heart problems, Kyzatrex is only prescribed for men with low testosterone caused by problems with the testicles, pituitary gland, or hypothalamus or genetic medical conditions.

Other serious side effects included on the Kyzatrex label include:

• Increased hematocrit in the blood, which can increase the risk of blood clots

• Worsening benign prostatic hyperplasia (enlarged prostate) or possibly increased risk of prostate cancer

• Venous thromboembolism, a type of blood clot

• Abuse of testosterone, such as using it to build muscle 

• Problems with sperm development

• Edema (swelling) with or without congestive heart failure

• Sleep apnea

• Changes to blood lipid levels

Who Shouldn’t Take Kyzatrex? 

Kyzatrex is not suitable for people:

• With breast cancer

• Who have or might have prostate cancer

• Who are pregnant (Kyzatrex is not approved for women in general)

• With allergies or sensitivities to Kyzatrex or any ingredients in it

It’s important to tell your healthcare provider about any medications you’re taking before you start Kyzatrex, because some medications can potentially interact with it. It’s especially important to mention if you’re taking:

• Insulin

• Blood thinners

• Medications that increase blood pressure

• Corticosteroids 

Are There Side Effects Associated With Stopping Kyzatrex?

If you stop Kyzatrex, your body’s testosterone levels will likely drop back to their original levels or even lower if your body slows its natural production.

It can be a long process for your body to start producing testosterone again. For example, after testosterone undecanoate injections, it can take 15 months for full recovery of testosterone levels.

If you’re planning or need to stop taking Kyzatrex, it’s important to talk to your healthcare provider before discontinuing therapy.

Kyzatrex is an oral TRT designed to raise testosterone levels without the need for injections, gels, or patches.

It’s only suitable for men with structural or genetic problems leading to testosterone deficiency. It also isn’t safe for men with uncontrolled high blood pressure.

The most common forms of TRT are injections and gels. Doctors often discourage oral testosterone due to the risk of liver problems. However, newer formulas like Kyzatrex are primarily absorbed by your gut’s lymphatic system and don’t seem to be associated with the same risk of liver damage as older formulations. 

All forms of TRT can potentially hurt fertility, so it’s important to discuss other treatment options with your doctor if you’re planning on having children. 

Enclomiphene citrate falls into a class of drugs called selective estrogen receptor modulators (SERMs). Unlike TRT, these medications stimulate your body to produce more testosterone, rather than simply supplementing your production. 

SERMs achieve this by stimulating your hypothalamus and pituitary gland to increase levels of two hormones produced in your anterior pituitary gland called luteinizing hormone (LH) and follicle-stimulating hormone (FSH). LH stimulates the production of testosterone in your testicles, and FSH stimulates the production of sperm. 

Your doctor may recommend enclomiphene if you’re planning on having children, as it may help mitigate reductions in fertility caused by TRT.

How do you take Kyzatrex?

Kyzatrex is an oral form of testosterone generally taken twice daily with food. The starting dose is usually 200 mg, but it may be adjusted depending on the results of your blood test.

Does Kyzatrex affect fertility?

Yes, like all forms of testosterone supplements, Kyzatrex can suppress natural testosterone production and may lower sperm count, making it unsuitable for men trying to conceive. If you’re planning on having children, it’s a good idea to talk to your doctor about alternative treatments.

What are the common side effects of Kyzatrex?

The most common side effect of Kyzatrex is high blood pressure, which can lead to serious cardiovascular complications for some men. It’s important to talk to your doctor about complications, especially if you have a history of high blood pressure.

Can women take Kyzatrex?

Kyzatrex is not an FDA-approved testosterone treatment for women. It’s also specifically contraindicated for pregnant women because it could harm the fetus. 

Low testosterone levels are associated with many potential health effects, such as fatigue, low sex drive, and trouble building muscle. Testosterone therapy with medications like Kyzatrex can potentially help ease these symptoms.

Kyzatrex is an option for men with low testosterone due to structural or genetic causes. It’s not suitable for men with uncontrolled high blood pressure, because it may lead to heart problems. 

If you’re thinking about starting testosterone replacement therapy, it’s important to discuss your options with a professional. You can talk to a healthcare provider through our telehealth service from the comfort of your home, no in-person clinic visit necessary.