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Enclomiphene

Enclomiphene is a prescription compounded medication used to treat low testosterone in men and support male fertility.

Medical Review byMike Bohl, MD, MBA, MPH, MS, ALMUpdated Aug 3, 2025

Medication Name

Enclomiphene

*image for illustrative purpose only

Enclomiphene

*image for illustrative purpose only

Basics

Enclomiphene is a non-steroidal selective estrogen receptor modulator (SERM) sometimes used to treat male secondary hypogonadism, or low testosterone caused by problems with the hypothalamus or pituitary gland. The medication is derived from another SERM called clomiphene citrate, and while enclomiphene is not approved by the United States Food and Drug Administration (FDA) to treat any condition on its own, it is available through compounding pharmacies.

Enclomiphene is designed to stimulate testosterone production while minimizing the estrogenic side effects sometimes seen with clomiphene, such as breast tissue growth. It works by blocking estrogen signals in the brain, which increases the release of certain hormones, like luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then tell the testicles to produce more natural testosterone.

Enclomiphene is taken as a daily pill, usually in doses of 12.5 milligrams (mg) to 25 mg.

Enclomiphene boosts testosterone while helping the body maintain its natural hormone production and sperm count, making it a good alternative to traditional testosterone replacement therapies for men who want to preserve their fertility.

*Enclomiphene Approved Uses

Enclomiphene is not approved as a drug in the United States

*Enclomiphene Drug Category

Selective estrogen receptor modulator

*Enclomiphene Side Effects

Information about enclomiphene is limited

Enclomiphene Cost

The cost of enclomiphene may vary depending on the dosage, quantity, where you buy it, and your insurance plan. Specific pricing information for this medication is not available.

*Interactions & Contraindications

Information about enclomiphene is limited

*Warnings & Precautions

Information about enclomiphene is limited

FAQs

No, enclomiphene is not approved by the FDA, but it’s sometimes prescribed for low testosterone or fertility issues in men and is available through compounding pharmacies. 

Enclomiphene and testosterone replacement therapy (TRT) are both used to treat low testosterone in men, but they work differently in the body. TRT directly replaces testosterone, while enclomiphene stimulates the body to produce more natural testosterone, which may help support fertility. The best option for you depends on your individual medical needs and goals.

Both enclomiphene and Clomid (clomiphene) are prescribed to treat low testosterone, but enclomiphene works in a more targeted way and may produce fewer side effects. However, the better treatment for you depends on a variety of factors that you should discuss with your healthcare provider.

Research has not found a significant link between enclomiphene and erectile dysfunction.

References

Information about enclomiphene is limited. It is the active isomer of clomiphene.

Editorial Standards

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

  1. Edwards RZ, et al. (2020). Improving low testosterone naturally. https://www.va.gov/WHOLEHEALTHLIBRARY/docs/Improving-Low-Testosterone-Naturally.pdf 

  2. Leslie SW, et al. (2024). Male infertility. https://www.ncbi.nlm.nih.gov/books/NBK562258/ 

  3. Mbi Feh MK, et al. (2024). Clomiphene. https://www.ncbi.nlm.nih.gov/books/NBK559292/ 

  4. Peters A, et al. (2023). Aromatase inhibitors. https://www.ncbi.nlm.nih.gov/books/NBK557856/ 

  5. Rodriguez KM, et al. (2016). Enclomiphene Citrate for the Treatment of Secondary Male Hypogonadism. https://pmc.ncbi.nlm.nih.gov/articles/PMC5009465/ 

  6. Saffati G, et al. (2024). Safety and efficacy of enclomiphene and clomiphene for hypogonadal men. https://pmc.ncbi.nlm.nih.gov/articles/PMC11491226/ 

  7. Sizar O, et al. (2023). Androgen replacement. https://www.ncbi.nlm.nih.gov/books/NBK534853/ 

  8. Zucker I, et al. (2022). Efficacy and Safety of Human Chorionic Gonadotropin Monotherapy for Men With Hypogonadal Symptoms and Normal Testosterone. https://pmc.ncbi.nlm.nih.gov/articles/PMC9246432/

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