Bupropion is a special antidepressant in the NDRI family. Notably, bupropion was the first modern antidepressant on the market (ahead of Prozac®), first approved by the FDA in 1985 and later in 1989 as an extended-release (XL) formula. Bupropion is sold under the brand names Wellbutrin®, Wellbutrin XL®, Wellbutrin SR®, Aplenzin®, and Zyban®.
Bupropion is approved by the FDA for the treatment of major depressive disorder (MDD), seasonal affective disorder, and smoking cessation (in combination with nicotine replacement therapy).
Bupropion is an NDRI and affects the balance of neurotransmitter chemicals in the brain, specifically norepinephrine and dopamine. This can ease symptoms of depression.