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Everything You Need to Know About PRF Hair Loss Treatment

Vicky Davis

Reviewed by Vicky Davis, FNP

Written by Rachel Sacks

Published 05/15/2023

Have questions about PRF hair restoration? We’ve got answers.

If you feel like you’re dealing with dramatic hair loss, you can take comfort in the fact that you’re not alone. Two in three men will experience some hair loss by the age of 35, while approximately 85 percent will have “significantly thinning hair” by the age of 50, according to the American Hair Loss Association.

You might be familiar with hair transplants as a potential remedy. But you may not be as familiar with platelet-rich fibrin (PRF), a medical treatment for hair restoration.

What is PRF hair restoration? Is it a cost-effective and, more importantly, safe way to encourage natural hair growth?

This guide will explore everything there is to know about this type of hair restoration therapy, including how it works, whether it’s safe, its effectiveness and PRF hair restoration cost.

What Is PRF Hair Restoration?

Platelet-rich fibrin hair treatment — or platelet-rich fibrin hair restoration — is a hair restoration surgery that involves injecting platelet-rich plasma (PRP) into the scalp to stimulate hair growth.

Platelet-rich plasma is a combination of plasma (the liquid portion of blood) and platelets, a type of blood cell that helps with healing throughout the body. Simply put, platelet-rich plasma is the blood that contains more platelets than normal.

Platelets can trigger cell reproduction and stimulate tissue regeneration in the treated area. PRP injections can be effective in treating both male and female pattern hair loss and baldness — also known as androgenic alopecia. They can also help stimulate hair regrowth after hair transplants.

Platelet-rich fibrin is considered an advanced version of platelet-rich plasma that uses fibrin, a protein generated by the body during blood clot formation.

How Does PRF Hair Restoration Work?

Both platelet-rich fibrin and PRP are collected in the same way. A blood sample is collected and then placed in a machine that rapidly spins the sample — a process known as centrifugation — separating the blood components.

However, there are differences between platelet-rich plasma and platelet-rich fibrin that make PRF hair restoration the preferred method.

Platelet-rich plasma is processed at a higher centrifuge speed and through a double centrifugation process, while PRF goes through a slower speed of centrifugation.

This slower speed of centrifugation for PRF allows white blood cells and stem cells to remain within the platelet layer instead of being separated into three distinct layers. This gives PRF an increased concentration of growth factors, whether used for wound healing or hair regrowth.

After the fibrin is separated and collected from the blood sample, it’s administered to the scalp via direct injections. The entire process typically takes less than 10 minutes. PRF treatments are usually given every six to eight weeks, with three treatments minimum.

After hair replacement surgery, it’s recommended to not wash your hair for eight hours post-procedure and to avoid sun exposure for at least a week.

New hair growth may begin within three to six months of treatment.

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Side Effects of PRF Hair Treatment

Similar to other hair transplant treatments, PRF hair restoration treatment can have potential side effects.

You may experience mild pain, swelling, soreness and minor bruising at the injection sites or on your scalp from the needle.

In a review of three patients who underwent PRF hair restoration treatments, mild bruising and inflammation of the scalp only lasted for a few days, and no pain medication was necessary.

Since PRF is extracted from your blood with no additives — as opposed to platelet-rich plasma to extract fibrin — this treatment is extremely safe, with no risk of allergic reaction and very little risk of infection or complication.

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How Much Does PRF Hair Treatment Cost?

PRF hair restoration costs can vary, but due to the advanced effects of platelet-rich fibrin, patients can expect it to be more expensive than platelet-rich plasma.

Platelet-rich plasma treatments can cost between $500 and $2,500. The cost of PRF hair restoration has a ballpark estimate of $600 to $900 per treatment, depending on the results you want.

Costs can vary depending on location, facility and the expertise of the doctor performing the treatment. We should also note that few insurance plans cover the cost of PRF treatment.

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Everything You Need to Know About PRF Hair Loss Treatment

While the U.S. Food and Drug Administration (FDA) has only approved the use of PRP in bone graft treatments, some healthcare providers may use the treatment to address other health issues — including hair loss.

Platelet-rich fibrin hair restoration is a non-surgical treatment that’s beneficial for a common type of hair loss known as androgenic alopecia or male pattern baldness. A blood sample from the patient is used to gather platelets and a protein called fibrin. These are injected into the scalp to promote hair growth.

PRF is fairly successful, and people may like the idea of using their cells to stimulate natural hair growth. However, more research is needed on the success rates, and treatments can be costly.

Hair restoration treatments are one way to treat male pattern hair loss — but they’re not the only option.

The two most common medical treatments for hair loss are minoxidil (Rogaine®) and finasteride (Propecia®). You can also explore more hair loss treatments online and discuss whether PRF hair restoration is right for you with a healthcare provider.

10 Sources

  1. McAndrews, P. J. (n.d.). Men's Hair Loss / Introduction. American Hair Loss Association. Retrieved from https://www.americanhairloss.org/men_hair_loss/introduction.html
  2. Arora, R., & Shukla, S. (2019). Injectable-Platelet-Rich Fibrin-Smart Blood with Stem Cells for the Treatment of Alopecia: A Report of Three Patients. International Journal of Trichology, 11(3), 128-131. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6580805/
  3. Platelet-Rich Plasma (PRP) Injections. (n.d.). Johns Hopkins Medicine. Retrieved from https://www.hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment
  4. Saluja, H., Dehane, V., & Mahindra, U. (2011). Platelet-Rich fibrin: A second generation platelet concentrate and a new friend of oral and maxillofacial surgeons. Annals of Maxillofacial Surgery, 1(1), 53-57. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3591032/
  5. Naik, B., Karunakar, P., Jayadev, M., & Marshal, V. R. (2013). Role of Platelet rich fibrin in wound healing: A critical review. Journal of Conservative Dentistry : JCD, 16(4), 284-293. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740636/
  6. Pavlovic, V., Ciric, M., Jovanovic, V., Trandafilovic, M., & Stojanovic, P. (2020). Platelet-rich fibrin: Basics of biological actions and protocol modifications. Open Medicine, 16(1), 446-454. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7985567/
  7. PRF Hair Restoration Atlanta GA, DERM CLINIC M.D. (n.d.). Derm Clinic M.D. Retrieved from https://www.dermclinicmd.com/med-spa-services/hair-treatments/prf-hair-restoration/
  8. Understanding Post-Injection Inflammation. (n.d.). Health Library. Retrieved from https://myhealth.ucsd.edu/Search/3,90744
  9. Jones, I. A., & Togashi, R. C. (2018). The Economics and Regulation of PRP in the Evolving Field of Orthopedic Biologics. Current Reviews in Musculoskeletal Medicine, 11(4), 558-565. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6220002/
  10. 2021 Biological Device Application Approvals. (n.d.). FDA. Retrieved from https://www.fda.gov/vaccines-blood-biologics/development-approval-process-cber/2021-biological-device-application-approvals
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Vicky Davis, FNP

Dr. Vicky Davis is a board-certified Family Nurse Practitioner with over 20 years of experience in clinical practice, leadership and education. 

Dr. Davis' expertise include direct patient care and many years working in clinical research to bring evidence-based care to patients and their families. 

She is a Florida native who obtained her master’s degree from the University of Florida and completed her Doctor of Nursing Practice in 2020 from Chamberlain College of Nursing

She is also an active member of the American Academy of Nurse Practitioners.

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