Tlando

Tlando^® is an oral testosterone replacement therapy (TRT) medication approved by the United States Food and Drug Administration (FDA) to treat adult males with hypogonadism, a condition marked by low testosterone levels that can cause symptoms including fatigue, low libido, muscle loss, and mood disturbances.

Unlike traditional injectable or topical TRT, Tlando is taken orally and absorbed through the lymphatic system to help restore normal hormone levels. Clinical studies have shown that Tlando can effectively restore testosterone levels within a healthy range. The typical starting dose is two 112.5 milligram (mg) capsules taken twice-daily with food for optimal absorption.

Some potential side effects of Tlando include high blood pressure, polycythemia (increased red blood cell count), worsening benign prostatic hyperplasia (BPH), liver enzyme changes, and cardiovascular risks. Regular monitoring by a healthcare provider is essential to ensure safe and effective TRT use.  

While Tlando offers a non-invasive TRT option, it may not be suitable for everyone, particularly those with preexisting cardiovascular, liver, or prostate conditions.

Tlando (testosterone undecanoate) is indicated for:

• Testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone

Androgen

Most common adverse reactions (incidence ≥2%):

• Increased blood prolactin

• High blood pressure

• Increased hematocrit

• Upper respiratory tract infection

• Weight increased

• Headache

• Musculoskeletal pain

The price of Tlando may vary depending on the dosage, quantity, where you buy it, and your insurance plan. The average retail price of Tlando is about $945 for a month’s supply of 112.5 mg capsules, but coupons and discount cards may be available to bring down the price. The Tlando Preferred Pharmacy Network program allows eligible people to access Tlando for as little as $0 per month with insurance and $150 per month without insurance. 

There is currently no lower-cost generic version of Tlando available in the United States.

Tlando is only available by prescription from a healthcare provider. If you’re interested in taking this medication, make an appointment with your provider so they can assess your testosterone levels and discuss whether testosterone therapy is the right treatment for you based on factors like your health status, medical history, and symptoms.

• Carcinoma of the breast or known or suspected carcinoma of the prostate

• Women who are pregnant. Testosterone may cause fetal harm 

• Hypersensitivity to Tlando or any of its ingredients

• Hypogonadal conditions not associated with structural or genetic etiologies

• Drug interactions: Insulin, oral anticoagulants, corticosteroids, drugs that may also increase blood pressure

• Polycythemia

• Worsening of benign prostatic hyperplasia (BPH) and potential risk of prostate cancer

• Venous thromboembolism (VTE)

• Abuse of testosterone and monitoring of serum testosterone

• Potential for adverse effects on spermatogenesis

• Edema

• Sleep apnea

• Lipid changes

• Increases in prolactin

WARNING: BLOOD PRESSURE INCREASES

Tlando can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.

Before initiating Tlando, consider the patient’s baseline cardiovascular risk and ensure blood pressure is adequately controlled.

Periodically monitor for and treat new-onset hypertension or exacerbations of pre-existing hypertension and re-evaluate whether the benefits of Tlando outweigh its risks in patients who develop cardiovascular risk factors or cardiovascular disease on treatment.

Due to this risk, use Tlando only for the treatment of men with hypogonadal conditions associated with structural or genetic etiologies.

Beyond Tlando, there are other treatments for low testosterone or hypogonadism. Some treatments may be better suited to you than others. If you’re interested in an alternative to Tlando, consider connecting with a healthcare provider who can help you evaluate your options.

Other types of testosterone replacement therapy (sometimes called androgen replacement) include:

• Injectable testosterone, such as Aveed^® or Depo^®-Testosterone

• Implantable testosterone pellets, such as Testopel^®

• Other oral testosterone therapy medications, including Jatenzo^® and Kyzatrex^®

• Topical testosterone, such as Androderm^® (testosterone patch) and Testim^® (testosterone gel)

Alternatives to TRT that may help manage low testosterone in men include the following, which can signal the body to have or make more testosterone:

• Aromatase inhibitors like Arimidex^® (anastrozole)

• Human chorionic gonadotropin (hCG) or Ovidrel^®, a lab-made version of hCG

• Selective estrogen receptor modulators like Clomid (clomiphene)

Your healthcare provider may also prescribe non-medication alternatives that can support healthy testosterone levels naturally, including:

• Exercise

• Stress management

• Dietary improvements

• Getting enough sleep

• Weight loss

*This information is from the label for brand name Tlando^®. See the Full Prescribing Information for more complete information. Testosterone undecanoate, the active ingredient in Tlando, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient testosterone undecanoate.