Testosterone enanthate

Testosterone enanthate is an injectable form of testosterone used in hormone replacement therapy for adult men with hypogonadism, a condition where the body doesn’t produce enough testosterone. This treatment aims to restore healthy testosterone levels and alleviate symptoms of testosterone deficiency, such as fatigue, low libido, depression, reduced muscle mass, and decreased bone density. 

Testosterone enanthate is also used to treat delayed puberty in males and may sometimes be used in the treatment of metastatic breast cancer in females.

It is typically given by intramuscular injection every two to four weeks, but dosing intervals may vary based on each person’s needs and clinical response. It may also be given subcutaneously (under the skin) once a week.

People taking this medication may experience fluctuations in hormone levels between doses, which can potentially lead to variable symptom control and/or side effects such as acne, increased red blood cell count, fluid retention, and mood changes.

Xyosted (testosterone enanthate) injection is indicated for:

• Testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone

Androgen

The most commonly reported adverse reactions (>5%) were:

• Hematocrit increased

• High blood pressure

• PSA increased

• Injection site bruising

• Headache

The price of testosterone enanthate may vary depending on the dosage, quantity, where you buy it, and your insurance plan. The average retail price is about $146 per vial, but coupons and discount cards can lower the price to as low as $32.

• Men with carcinoma of the breast or known or suspected carcinoma of the prostate

• Women who are pregnant. Testosterone may cause fetal harm

• Known hypersensitivity to Xyosted or its ingredients

• Men with hypogonadal conditions not associated with structural or genetic etiologies

• Drug interactions: Androgens may decrease blood glucose, changes in anticoagulant activity may be seen with androgens, use of testosterone with corticosteroids may result in increased fluid retention, concomitant administration of medications that are known to increase blood pressure with Xyosted may lead to additional increases in blood pressure

• Monitor hematocrit approximately every 3 months to detect increased red blood cell mass and polycythemia

• Monitor patients with benign prostatic hyperplasia (BPH) for worsening signs and symptoms of BPH

• Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE) have been reported in patients using testosterone products

• Testosterone has been subject to abuse, typically at doses higher than recommended for the approved indication and in combination with other anabolic androgenic steroids

• Exogenous administration of androgens may lead to azoospermia

• Edema with or without congestive heart failure may be a complication in patients with preexisting cardiac, renal, or hepatic disease

• Sleep apnea may occur in those with risk factors

• Monitor prostatic specific antigen (PSA) and lipid concentrations periodically

• Depression and suicidal ideation and behavior, including completed suicide, have occurred during clinical trials in patients treated with Xyosted

WARNING: BLOOD PRESSURE INCREASES

Xyosted can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.

Before initiating Xyosted, consider the patient’s baseline cardiovascular risk and ensure blood pressure is adequately controlled.

Periodically monitor for and treat new-onset hypertension or exacerbations of pre-existing hypertension and re-evaluate whether the benefits of Xyosted outweigh its risks in patients who develop cardiovascular risk factors or cardiovascular disease on treatment.

Due to this risk, use Xyosted only for the treatment of men with hypogonadal conditions associated with structural or genetic etiologies.

*This information is from the label for brand name Xyosted^®. See the Full Prescribing Information for more complete information. Testosterone enanthate, the active ingredient in Xyosted, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient testosterone enanthate.