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Mederek

Mederek contains the active ingredient yohimbine, which has shown promise in improving erectile dysfunction and enhancing libido, but there’s limited research on its safety or effectiveness.

Medical Review byMike Bohl, MD, MBA, MPH, MS, ALMUpdated May 20, 2025

Medication Name

Mederek

*image for illustrative purpose only

Mederek

*image for illustrative purpose only

Basics

The active ingredient in Mederek is yohimbine. Yohimbine comes from the bark of the African yohimbe tree and is commonly used as a supplement and pharmaceutical compound promoted to help with erectile dysfunction (ED), high blood pressure, weight loss, and more.

When it comes to sexual health, yohimbine has been studied (mostly in animal trials) for its effect on erectile function and libido. It functions as an alpha-2 adrenergic receptor antagonist, which increases blood flow to the pelvic region, aiding in erection quality and sexual arousal. There is some evidence that yohimbine may improve erectile function in men with mild to moderate ED, particularly those with vascular (having to do with blood vessel problems) or psychological causes. 

Additionally, yohimbine has been studied for its role in enhancing libido by improving dopamine levels, which may increase sexual motivation and arousal. However, side effects can include increased heart rate, anxiety, hypertension, dizziness, and gastrointestinal issues.

Overall, there is evidence that yohimbine (the active ingredient in Mederek) may improve sexual function, but its safety and effectiveness aren’t well-researched and may vary depending on the individual.

*Mederek Approved Uses

Mederek (yohimbine) is not approved as a drug in the United States

*Mederek Drug Category

Mederek is not a drug; it is a supplement

*Mederek Side Effects

Information about Mederek is limited

Mederek Cost

The cost of Mederek or yohimbine may vary depending on where you buy it. 

Yohimbine supplements sold online range from about $11 for 120 capsules to about $30 for 60 capsules.

How To Get Mederek

Supplements containing yohimbine are available online, in certain pharmacies, and in other stores that sell supplements.

*Interactions & Contraindications

Information about Mederek is limited

  • Do not use yohimbe if you are taking a type of antidepressant medication called monoamine oxidase inhibitors, such as phenelzine (Nardil) and tranylcypromine (Parnate)

*Warnings & Precautions

  • Yohimbe has been associated with heart attacks and seizures

  • Because of inaccurate labeling and potential for serious side effects, yohimbe supplements have been restricted or banned in many countries

  • Yohimbe caused stomach problems, rapid heartbeat, anxiety, and high blood pressure, according to a study comparing calls about yohimbe and other substances made to the California Poison Control System between 2000 and 2006

  • Most yohimbe products don’t say how much yohimbine they contain

  • It might be unsafe for children to take yohimbe orally

  • Pregnancy/Breastfeeding: It might be unsafe to use yohimbe orally during pregnancy and while breastfeeding

Mederek Alternatives

There are more well-studied medications prescribed to treat ED. Some of these drugs may be better suited to you than others. Talk with your healthcare provider to learn more about which treatment may work best for you.

Oral medications that can treat ED include the following phosphodiesterase type 5 (PDE5) inhibitors:

Penile injection medications for ED include:

Combination medications such as Bimix, Trimix, and Quadmix

FAQs

There’s very little research on yohimbine and products that contain this active ingredient, so it’s difficult to say for sure whether it’s safe and effective for the majority of people.

Usually, the recommended dose of purified yohimbine is 5 to 10 milligrams three times a day.

It’s not clear. Yohimbine’s effect on ED and libido don’t seem to be connected to increased testosterone, but the research done so far is limited and mostly done in animals.

While some animal research has found that yohimbine might enhance the effects of Viagra’s active ingredient sildenafil, there hasn’t been enough research to confirm the safety and effectiveness of this combination in humans. Always talk to your healthcare professional before taking a new supplement, especially if you take prescription drugs.

References

*Information about Mederek® is limited. This information was taken, in part, from the National Center for Complementary and Integrative Health's website on Yohimbe.

  1. Jabir NR, et al. (2022). A literature perspective on the pharmacological applications of yohimbine. https://www.tandfonline.com/doi/full/10.1080/07853890.2022.2131330 

  2. LiverTox. (2020). Yohimbine. ​​https://www.ncbi.nlm.nih.gov/books/NBK548703/ 

  3. National Center for Complementary and Integrative Health. (2020). Yohimbe: Usefulness and Safety. https://www.nccih.nih.gov/health/yohimbe 

  4. Senbel AM, et al. (2008). Yohimbine enhances the effect of sildenafil on erectile process in rats. https://pubmed.ncbi.nlm.nih.gov/18418393/

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