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Kyzatrex

Kyzatrex® (testosterone undecanoate) is a prescription oral testosterone replacement therapy used to treat adult men who have low or no testosterone due to certain medical conditions.

Medical Review byMike Bohl, MD, MBA, MPH, MS, ALMUpdated May 20, 2025

Medication Name

Kyzatrex

*image for illustrative purpose only

Kyzatrex

*image for illustrative purpose only

Basics

Kyzatrex® is an oral medication containing testosterone that’s prescribed to adult males with conditions associated with low or no naturally occurring testosterone. It works by replacing or supplementing the body's natural testosterone levels.

Kyzatrex is available in capsule form with strengths of 100 mg, 150 mg, and 200 mg. The recommended dosage is typically taken twice daily with food, once in the morning and once in the evening.

Common side effects include increased blood pressure, headache, joint or back pain, diarrhea, constipation, anxiety, leg swelling, and increased prostate-specific antigen (PSA) levels. Serious side effects may involve cardiovascular events, polycythemia (elevated red blood cell count), worsening of benign prostatic hyperplasia (BPH), potential risk of prostate cancer, venous thromboembolism (blood clots), and sleep apnea. Regular monitoring of blood pressure, red blood cell count, and prostate health is advised during treatment.

*Kyzatrex Approved Uses

Kyzatrex (testosterone undecanoate) is indicated for:

  • Testosterone replacement therapy in adult males for conditions associated with a deficiency or absence of endogenous testosterone

*Kyzatrex Drug Category

Androgen

*Kyzatrex Side Effects

Most common adverse reactions (incidence ≥2%):

  • High blood pressure

Kyzatrex Cost

The price of Kyzatrex may vary depending on the dosage, quantity, and where you buy it. The average retail price of Kyzatrex ranges from about $400 to $1,100 for a month’s supply, but coupons and discount cards may be available to bring down the price. 

According to the drug’s website, Kyzatrex is a cash-pay medication, meaning it’s not covered by insurance. There is no lower-cost generic form of Kyzatrex currently available.

How To Get Kyzatrex

Kyzatrex is only available via prescription from a healthcare provider. If you’re interested in taking this medication, make an appointment with your provider so they can assess your testosterone levels and discuss whether testosterone therapy is the right treatment for you and the symptoms you’re experiencing.

*Interactions & Contraindications

  • Carcinoma of the breast or known or suspected carcinoma of the prostate

  • Women who are pregnant. Testosterone may cause fetal harm

  • Hypersensitivity to Kyzatrex or any of its ingredients

  • Hypogonadal conditions not associated with structural or genetic etiologies

  • Drug interactions: Insulin, oral anticoagulants, corticosteroids, drugs that may also increase blood pressure

*Warnings & Precautions

  • Polycythemia

  • Worsening of benign prostatic hyperplasia (BPH) and potential risk of prostate cancer

  • Venous thromboembolism (VTE)

  • Abuse of testosterone and monitoring of serum Ttstosterone

  • Potential for adverse effects on spermatogenesis

  • Edema

  • Sleep apnea

  • Lipid changes

*Kyzatrex Boxed Warning

WARNING: BLOOD PRESSURE INCREASES

Kyzatrex can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.

Before initiating Kyzatrex, consider the patient's baseline cardiovascular risk and ensure blood pressure is adequately controlled.

Periodically monitor for and treat new-onset hypertension or exacerbations of pre-existing hypertension and re-evaluate whether the benefits of Kyzatrex outweigh its risks in patients who develop cardiovascular risk factors or cardiovascular disease on treatment.

Due to this risk, use Kyzatrex only for the treatment of men with hypogonadal conditions associated with structural or genetic etiologies.

Kyzatrex Alternatives

There are other treatments for low testosterone, sometimes called hypogonadism. Some treatments may be better suited to you than others. If you’re interested in an alternative to Kyzatrex, consider connecting with a healthcare provider who can help you evaluate your options.

Other types of testosterone replacement therapy (TRT) (sometimes called androgen replacement) include:

  • Injectable testosterone, such as Aveed® or Depo®-Testosterone

  • Implantable testosterone pellets, such as Testopel®

  • Other oral testosterone therapy medications, including Jatenzo® and Tlando®

  • Topical testosterone, such as Androderm® (testosterone patch) and Testim® (testosterone gel)

Alternatives to TRT that may help manage low testosterone in men include the following, which can signal the body to have or make more testosterone:

  • Aromatase inhibitors like Arimidex® (anastrozole)

  • Human chorionic gonadotropin (hCG) or Ovidrel®, a lab-made version of hCG

  • Selective estrogen receptor modulators like Clomid (clomiphene)

Your healthcare provider may also prescribe non-medication alternatives that can support healthy testosterone levels, including:

  • Exercise

  • Stress management

  • Dietary improvements

  • Getting enough sleep

  • Weight loss

FAQs

In a study of 166 people with low testosterone who took oral testosterone undecanoate (the active ingredient in Kyzatrex), more than 87 percent saw their blood testosterone levels return to normal within three to four months. 

Yes. Kyzatrex is a controlled substance because it contains testosterone. Controlled substances are tightly controlled by the government because they may be abused or cause addiction.

Kyzatrex is designed to be absorbed immediately by your lymphatic system, bypassing the liver and avoiding the risk of liver toxicity associated with certain other forms of oral testosterone medications.

Kyzatrex is meant to be taken with food, which helps your body better absorb the medication.

References

*This information is from the label for brand name Kyzatrex®. See the Full Prescribing Information for more complete information. Testosterone undecanoate, the active ingredient in Kyzatrex, may also be the active ingredient in other medications, and this information may not be accurate for all medications that include the active ingredient testosterone undecanoate.

  1. Asghar AA, et al. (2022). Kyzatrex: Oral testosterone replacement therapy. https://pmc.ncbi.nlm.nih.gov/articles/PMC9577662/ 

  2. Edwards RZ, et al. (2020). Improving low testosterone naturally. https://www.va.gov/WHOLEHEALTHLIBRARY/docs/Improving-Low-Testosterone-Naturally.pdf 

  3. GoodRx. (n.d.). Kyzatrex prices, coupons, and savings tips. https://www.goodrx.com/kyzatrex 

  4. Ide V, et al. (2021). Treatment of men with central hypogonadism: alternatives for testosterone replacement therapy. https://www.mdpi.com/1422-0067/22/1/21 

  5. Kyzatrex.com. (n.d.). FAQs on Kyzatrex: Low T Resources. https://www.kyzatrex.com/faq/ 

  6. National Cancer Institute. (n.d.). Definition of controlled substance. https://www.cancer.gov/publications/dictionaries/cancer-terms/def/controlled-substance 

  7. National Library of Medicine. (2023). DailyMed: Kyzatrex. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7f7167a7-2a25-47e2-acf5-33f499fce971 

  8. Sizar O, et al. (2023). Androgen replacement. https://www.ncbi.nlm.nih.gov/books/NBK534853/

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