Compare common side effects, interactions, warnings, and more.
Enclomiphene
*image for illustrative purpose only
Zuclomiphene
*image for illustrative purpose only
Enclomiphene
*image for illustrative purpose only
Zuclomiphene
*image for illustrative purpose only
Enclomiphene is a non-steroidal selective estrogen receptor modulator (SERM) sometimes used to treat male secondary hypogonadism, or low testosterone caused by problems with the hypothalamus or pituitary gland. The medication is derived from another SERM called clomiphene citrate, and while enclomiphene is not approved by the United States Food and Drug Administration (FDA) to treat any condition on its own, it is available through compounding pharmacies.
Enclomiphene is designed to stimulate testosterone production while minimizing the estrogenic side effects sometimes seen with clomiphene, such as breast tissue growth. It works by blocking estrogen signals in the brain, which increases the release of certain hormones, like luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then tell the testicles to produce more natural testosterone.
Enclomiphene is taken as a daily pill, usually in doses of 12.5 milligrams (mg) to 25 mg.
Enclomiphene boosts testosterone while helping the body maintain its natural hormone production and sperm count, making it a good alternative to traditional testosterone replacement therapies for men who want to preserve their fertility.
Zuclomiphene is one of two stereoisomers that make up the medication clomiphene (the other being enclomiphene). Clomiphene is FDA approved for the treatment of ovulatory dysfunction in women desiring pregnancy, and it is sometimes used off label in men with low testosterone. Zuclomiphene, on its own, is not used as a medication for any medical condition.
Selective estrogen receptor modulator
Nonsteroidal triphenylethylene derivative with selective estrogen receptor modulator-like properties
Enclomiphene is not approved as a drug in the United States
Zuclomiphene is not approved as a drug in the United States
Typically taken orally
Often prescribed at 6.25 mg, 12.5 mg, and 25 mg doses
Information about zuclomiphene is limited
Information about enclomiphene is limited
Information about zuclomiphene is limited
Information about enclomiphene is limited
Information about zuclomiphene is limited
Information about enclomiphene is limited
Information about zuclomiphene is limited
Information about enclomiphene is limited. It is the active isomer of clomiphene.
*Information about zuclomiphene is limited
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