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Clomid for Men: Uses & How it Works

Kelly Brown MD, MBA

Reviewed by Kelly Brown MD, MBA

Written by Erica Garza

Published 05/28/2022

Updated 07/16/2024

Over the last few decades, fertility drugs like Clomid® and treatments like IVF (in-vitro fertilization) have made the life-changing difference between starting a family or not.

Clomid (the brand name for clomiphene citrate) is an FDA-approved medication for female infertility. But some medical providers prescribe Clomid for men off-label if they’re dealing with infertility or low testosterone levels (male hypogonadism). 

Clomid boosts luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the body. The result? An overall increase in sperm and testosterone production. But seeing the full results can take time — often weeks or months.

Looking into fertility treatments or medication for low testosterone? Here, we’ll tell you if Clomid can help, signs the medication is working, and side effects you should know about.

Clomid (clomiphene citrate) is in a class of drugs known as selective estrogen receptor modulators (SERMs). The medication is sometimes prescribed off-label to treat male factor infertility and low testosterone in men.

This means that although Clomid isn’t approved by the FDA (U.S. Food and Drug Administration) for men, it’s commonly prescribed by healthcare providers anyway.

For now, Clomid is only FDA-approved for the treatment of two hormonal imbalance-related fertility issues in women. Both have to do with how the female body ovulates, or releases an egg from the ovary:

  • Anovulatory infertility (or anovulation). This means no egg is released during the menstrual cycle. In other words, ovulation doesn’t happen.

  • Oligo-ovulatory infertility (or oligo-ovulation). These fertility issues are related to irregular egg releases, meaning ovulation happens but not in a predictable cycle.

These fertility issues may be caused by a variety of factors, including polycystic ovary syndrome (PCOS) or prior birth control use. In any case, they’re very specific types of infertility.

With both anovulation and oligo-ovulation, the cause of infertility is a lack of normal ovulation. And in either scenario, Clomid helps induce ovulation.

When it comes to Clomid men’s medication, however, there’s less clarity about how it’s used and how effective it is.

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The drug competes with estradiol (a version of the hormone estrogen) to act on estrogen receptors in the body. This amps up the production of (LH) and (FSH), the hormones responsible for making testosterone and sperm in the testes.

Due to its ability to support spermatogenesis (aka sperm production), healthcare providers commonly prescribe Clomid for men struggling with signs of infertility. 

According to research, many patients see an increase in sperm production within about three months of using clomiphene.

Clomiphene is also possibly effective in treating hypogonadism — also known as low testosterone or “low T.”

This feature has occasionally been used as a performance enhancer by healthy athletes and bodybuilders to boost muscle mass by increasing serum testosterone levels.

There’s a fairly straightforward timeline in which this medication will “kick in” for women, but things are a little less predictable when it comes to Clomid for men.

Because of the length of time it takes for a sperm to be created and used in the ejaculation process, Clomid can take several (as in three to four) months to work. It might take even longer for some guys — everyone’s different. 

You’ll start taking Clomid and have check-ins with your healthcare provider to see how your body is responding to the medication. Through testing, they can tell you if and when it starts working.

Clomid has been proven to successfully boost sperm concentration (the amount of sperm you make) and sperm motility (how well sperm swims). But outcomes can vary — and again, it might take longer for some men to see results.

Here are a couple of signs Clomid is working:

  • Successful conception. The most obvious sign Clomid for fertility is working is that your partner gets a positive pregnancy test after trying to conceive.

  • Rising testosterone. Generally, Clomid is beginning to work if your testosterone levels or your sperm count are rising. But again, it can take a few months for that to happen.

A healthcare provider can run tests to see if you’re experiencing hormonal changes and increased sperm production.

It’s going to take a lot of patience — something that can be difficult if you’re experiencing side effects or have been on a fertility journey for a while.

A healthcare provider might give you 25 to 50 milligrams (mg) of Clomid to start. Then they may increase or decrease your dosage as needed based on lab results or side effects you’re experiencing.

Your provider will work with you on an optimal dosing strategy for your needs. It might include days on (taking the medication) and days off (not taking the medication).

Some men continue taking the medication until it’s no longer needed — which means different things for different people, of course. If you’re using it for male infertility, that’ll mean a successful pregnancy for you and your partner.

Choose your chew

Full disclosure: Clomid side effects can be pretty rough. 

For men specifically, there’s some limited research suggesting Clomid can increase the risk of testicular tumors. So, if you and your healthcare provider decide it’s the right treatment for you, ask about the best way to monitor for these.

Other potential side effects of clomiphene include: 

  • Hot flashes

  • Gynecomastia (breast growth)

  • Nausea

  • Vomiting

  • Headache

  • Dizziness

  • Fatigue

  • Mood swings

  • Worsened psychiatric symptoms

Some Clomid symptoms can be a result of overdose. And many, like nausea and dizziness, are dose-dependent and can get worse the more you take.

So make sure you take Clomid exactly as prescribed. No fiddling around.

Serious side effects of Clomid include:

  • Pancreatitis

  • Vision loss

  • Liver damage

If you experience any of these, seek medical attention immediately. 

Also, clomiphene shouldn’t be used if you’re dealing with uncontrolled thyroid disease, a pituitary gland tumor, or adrenal dysfunction.

Male factor infertility is a complicated condition caused by any number of factors associated with reproductive health. As a result, there’s no single effective treatment that’ll fix your problems — at least, not one we can recommend right now. 

The best course of treatment will be recommended by a healthcare professional after they’ve done some significant testing to determine the cause(s) of your infertility.

A heads up: Their medical advice will likely include changes to your lifestyle if there are any areas where those habits might increase your risk of infertility. 

Lifestyle changes to boost male fertility might include:

  • Quitting smoking or drinking less alcohol

  • Avoiding recreational drugs

  • Lowering your stress levels

  • Improving your nutrition or taking dietary supplements to address a nutrient deficiency

  • Not using potentially toxic lubricants

  • Losing or gaining weight (obesity is a major contributor to infertility)

Some research says constrictive underwear and other tight clothes might be a contributing risk factor for infertility in men. While we’re not convinced this is a primary cause of infertility, wearing looser, breathable clothing can’t hurt.

Though treatment of male infertility can be stressful, options are available. Clomid is just one potential solution, but a fertility specialist can go over many more with you. Keep the conversation open and trust their guidance. Good things take time.

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Clomid men’s medication can be an effective alternative to testosterone replacement therapy (TRT) for the treatment of low testosterone — and it can have fewer side effects.

If you’re experiencing male infertility or need fertility treatments for low sperm count, addressing the problem is the first step to finding a solution that works for you.

Before you take action, remember these few pieces of wisdom on Clomid for men: 

  • Male infertility is nothing to be ashamed of. It’s not representative of your masculinity. And while healthy lifestyle changes can help, infertility doesn’t mean you did anything wrong.

  • You can do something about it. In many cases, male infertility can be fixed. Talking to a healthcare professional about your concerns, discussing health issues, and sharing details about how long you’ve been trying to conceive — all of this will help you get a tailored, you-specific solution to the problem.

If you’re more comfortable connecting with a healthcare provider virtually, Hims primary care services are a great place to start.

11 Sources

  1. Alizadeh Y, et al. (2021). Presumed clomiphene-induced optic neuropathy: A case report. https://chooser.crossref.org/?doi=10.18502%2Fijrm.v19i5.9257
  2. Aussedat M, et al. (2017). Clomiphene for the Treatment of Male Infertility: A Case Report of Mood Change and a Literature Overview. https://www.eurekaselect.com/article/84155
  3. Clomid (clomiphene citrate) tablets label - Food and Drug Administration. (n.d.). https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/016131s026lbl.pdf
  4. Da Ros CT, et al. (2022). The role of clomiphene citrate in late onset male hypogonadism. https://www.google.com.rproxy.goskope.com/url?q=https://www.scielo.br/j/ibju/a/Km7VRZB5bmZVJTmvgCnfj8G/?lang%3Den&sa=D&source=docs&ust=1721098728609922&usg=AOvVaw0GLjuSUWp-YMQrkmrFke7p
  5. Huijben M, et al. (2023). Clomiphene citrate for male infertility: A systematic review and meta-analysis. https://www.google.com.rproxy.goskope.com/url?q=https://onlinelibrary.wiley.com/doi/10.1111/andr.13388&sa=D&source=docs&ust=1721098751832129&usg=AOvVaw10euJpwOM7BRjRiJ0BtI3e
  6. Leslie SW, et al. (2022). Male Infertility. https://www.ncbi.nlm.nih.gov/books/NBK562258/
  7. Mbi Feh MK, et al. (2022). Clomiphene. https://www.ncbi.nlm.nih.gov/books/NBK559292/
  8. Mikityanskiy YE, et al. (2016). Clomiphene Citrate-Induced Acute Pancreatitis. https://journals.lww.com/ajg/fulltext/2016/10001/clomiphene_citrate_induced_acute_pancreatitis_in_a.1169.aspx
  9. Mínguez-Alarcón L, et al. (2018). Type of underwear worn and markers of testicular function among men attending a fertility center. https://academic.oup.com/humrep/article/33/9/1749/5066758
  10. Nilsson A, et al. (1985). Testicular germ cell tumors after clomiphene therapy for subfertility. https://www.auajournals.org/doi/10.1016/S0022-5347%2817%2947294-6
  11. Zhang HM, et al. (2018). Liver injury induced by clomiphene citrate: A case report and literature reviews. https://onlinelibrary.wiley.com/doi/10.1111/jcpt.12654
Editorial Standards

Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations. We strive to use primary sources and refrain from using tertiary references. See a mistake? Let us know at [email protected]!

This article is for informational purposes only and does not constitute medical advice. The information contained herein is not a substitute for and should never be relied upon for professional medical advice. Always talk to your doctor about the risks and benefits of any treatment. Learn more about our editorial standards here.

Kelly Brown MD, MBA
Kelly Brown MD, MBA

Dr. Kelly Brown is a board certified Urologist and fellowship trained in Andrology. She is an accomplished men’s health expert with a robust background in healthcare innovation, clinical medicine, and academic research. Dr. Brown was previously Medical Director of a male fertility startup where she lead strategy and design of their digital health platform, an innovative education and telehealth model for delivering expert male fertility care.

She completed her undergraduate studies at University of North Carolina at Chapel Hill (go Heels!) with a Bachelor of Science in Radiologic Science and a Minor in Chemistry. She took a position at University of California Los Angeles as a radiologic technologist in the department of Interventional Cardiology, further solidifying her passion for medicine. She also pursued the unique opportunity to lead departmental design and operational development at the Ronald Reagan UCLA Medical Center, sparking her passion for the business of healthcare.

Dr. Brown then went on to obtain her doctorate in medicine from the prestigious Northwestern University - Feinberg School of Medicine and Masters in Business Administration from Northwestern University - Kellogg School of Management, with a concentration in Healthcare Management. During her surgical residency in Urology at University of California San Francisco, she utilized her research year to focus on innovations in telemedicine and then served as chief resident with significant contributions to clinical quality improvement. Dr. Brown then completed her Andrology Fellowship at Medical College of Wisconsin, furthering her expertise in male fertility, microsurgery, and sexual function.

Her dedication to caring for patients with compassion, understanding, as well as a unique ability to make guys instantly comfortable discussing anything from sex to sperm makes her a renowned clinician. In addition, her passion for innovation in healthcare combined with her business acumen makes her a formidable leader in the field of men’s health.

Dr. Brown is an avid adventurer; summiting Mount Kilimanjaro in Tanzania (twice!) and hiking the incredible Torres del Paine Trek in Patagonia, Chile. She deeply appreciates new challenges and diverse cultures on her travels. She lives in Denver with her husband, two children, and beloved Bernese Mountain Dog. You can find Dr. Brown on LinkedIn for more information.

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