FDA-approved

Generic for Cymbalta^®

Duloxetine

Starting at $49/mo

Getting psychiatric care for anxiety and depression has never been simpler. Consult with a licensed healthcare provider to determine whether a medication like duloxetine could be right for you.

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Details

Prescribed by a healthcare provider experienced in treating anxiety & depression, if appropriate
Unlimited provider messaging
Unlimited dosage adjustments

What is duloxetine?

Duloxetine is an antidepressant, specifically an SNRI (serotonin-norepinephrine reuptake inhibitor). Duloxetine was first approved by the FDA in 2004 and sold under the brand names Cymbalta and others. Duloxetine was first approved by the FDA in 2004 and sold under the brand names Cymbalta® and others.

Duloxetine uses

Duloxetine is FDA approved to treat generalized anxiety disorder (GAD) and major depressive disorder (MDD). It is also indicated for certain other conditions related to nerve pain including diabetic peripheral neuropathic pain, fibromyalgia, and chronic musculoskeletal pain. Treatment for nerve pain is not available through our platform. Those seeking care for nerve pain should consider seeing a medical provider outside our platform to evaluate potential options for treatment.

How duloxetine works

Duloxetine is an SNRI and works by discouraging nerves in the brain (neurons) from absorbing two substances, serotonin and norepinephrine, thereby increasing their levels in the brain. This can have beneficial effects on psychiatric disorders, such as anxiety and depression.

Only available if prescribed after an online consultation with a healthcare provider.

Controlled substances such as Xanax and Adderall are not available through our platform.

This page has been medically reviewed by Sylvia Valadez, MSN, APRN, FNP-BC.

Important safety information

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Answer a few questions about your symptoms and health history. A licensed provider will review through our platform.

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Duloxetine

What’s an SNRI?

Serotonin-norepinephrine reuptake inhibitors (SNRIs) zero in on mood-affecting chemicals in the brain and help to regulate their levels to improve your symptoms. Nice, right?

The science of duloxetine

Your brain naturally produces chemicals that make you feel good, like serotonin and norepinephrine. Duloxetine keeps neurons from reabsorbing these chemicals so that you have more of them available in your brain. Long story short? This can help relieve symptoms of anxiety and depression.

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Featured reviews

Real results from guys like you

Kyle

I truly felt like Hims took my symptoms and how I felt into careful consideration. Now, I know I can reach out to my practitioner at any time on my phone and can make adjustments as needed.

Sam

I was able to secure an online appointment way faster than I had imagined and was back on my regular medication schedule within maybe a week or so of that consultation.

Nick

I found support that I rarely experienced in a traditional clinical setting. They made me feel like there was no reason not to get help. No judgment. No unnecessary tests. Just support and solutions.

Jeff

The process could not have been easier! I submitted a form, and within the day I was chatting with a provider. I never felt judged.

Justin

It has given me the treatment I needed without the hassle and perceived stigmas. I can’t thank Hims enough.

These customers’ results have not been independently verified. Individual results will vary. Customers were given free product.

75%

Feel better

Over 75% of Hims customers who checked in with their provider reported improvements in their mental health symptoms.¹

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1. Results vary. Data were self-reported between 11/26/2021 and 08/01/2022 by Hims customers who 1) signed up between 11/04/2021 and 05/04/2022; 2) were prescribed antidepressant medication by a provider after their first consultation on the Hims platform; and 3) had an active subscription for such antidepressant medication through the Hims platform within 90 days after signing up.

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Frequently asked questions about duloxetine

How does duloxetine (generic for Cymbalta) make you feel?

When taken as prescribed, duloxetine has been shown to treat symptoms of anxiety and depression. Notably, studies show duloxetine has an analgesic effect on painful physical symptoms of MDD, and this effect is partially independent of improvement in MDD.

How long does it take for duloxetine (generic for Cymbalta) to work?

Duloxetine was shown to be effective as a treatment for anxiety and depression in clinical trials lasting 8-10 weeks. Consult with your healthcare provider if you do not think your condition is getting better.

Does duloxetine (generic for Cymbalta) cause weight gain?

According to one study in JAMA Psychiatry, duloxetine was associated with a slight increase in weight after initial prescription. However, this increase was approximately 1% of body weight over 12 months, which was less than other antidepressant medication options.

Does duloxetine (generic for Cymbalta) help with anxiety?

Duloxetine is FDA-approved to treat generalized anxiety disorder. However, duloxetine is not for people who experience occasional anxiety caused by normal life events.

How can I buy duloxetine online?

Start a consultation with a psychiatrist or other qualified psychiatry provider online through our platform. If prescribed duloxetine, genuine duloxetine hcl will be shipped to you discreetly. You’ll have ongoing check-ins with a health care provider to evaluate whether your treatment plan is working.

What are the side effects of duloxetine?

While the risk of side effects that are serious is low, you should seek medical advice or medical help if you experience any of the following side effects:

suicidal thoughts
easy bruising or uncontrolled bleeding
mania
blurred vision
yellowing of the eyes or skin
excessive headaches
vomiting or coughing up blood
serious allergic reaction (anaphylaxis)
lightheadedness, loss of coordination, or low blood pressure
difficulty breathing or tightness in the chest

Discuss any side effects you experience with your provider.

What are potential drug interactions with duloxetine?

Duloxetine can interact with a variety of substances, including some common medications as well as supplements. Substances that may interact include but are not limited to: other antidepressants, monoamine oxidase inhibitors (MAOIs), nonsteroidal anti-inflammatory drugs (NSAIDs), St. John's Wort, L-tryptophan and more. Risk of serotonin syndrome (toxicity when there is too much serotonin in the system) increases when combined with any substance that increases serotonin.

Who should not take duloxetine?

People who suffer from medical conditions such as uncontrolled narrow-angle glaucoma, kidney disease, liver problems or high blood pressure should not take duloxetine without discussing with their healthcare provider. Additionally, be sure to mention if you have any of the following medical conditions:

diabetes
hyponatremia
mania
seizures
urinary tract obstruction

Before taking duloxetine, you should also talk to your healthcare professional about any over-the-counter or prescription drugs you are currently taking. Some important medications to mention include antihistamines, blood thinners, MAOIs, amphetamines, aspirin, warfarin, ibuprofen, rasagiline, and other selective serotonin reuptake inhibitors (SSRIs).

What should I do if I miss a dose of duloxetine?

If you miss a dose of duloxetine, take the missed dose as soon as you remember. However, if it is near the time of your next dose, skip the missed dose. If you miss more than one dose in a row, be sure to notify your healthcare provider.

Can I drink alcohol with duloxetine?

On their own, both Cymbalta (duloxetine) and alcohol have the potential to cause liver damage or worsened depression. Taken together, the risk for serious side effects may increase. Seek medical advice from your healthcare professional before drinking alcohol while taking duloxetine.

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