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Metabolic health

Uric Acid

Also known as: Serum Uric Acid, Serum urate, Uric acid blood test, UA test, 24-hour urinary uric acid (for kidney excretion assessment)

A uric acid test measures how much uric acid is circulating in your blood. Uric acid forms when your body breaks down substances called purines, which are found in certain foods (like red meat, shellfish, certain vegetables, and alcohol) and in your body’s own cells.

When uric acid levels are too high, crystals can build up in joints or tissues, causing gout — the most common type of inflammatory arthritis. Levels that stay high may also contribute to kidney stones or signal kidney-function problems.

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Key takeaways

  • Sample required: Blood (serum) or sometimes 24-hour urine

  • Tests for: The amount of uric acid, a byproduct of purine metabolism, in the blood

  • Healthy range: Generally, for adult men, it’s 4.0 - 8.0 milligrams per deciliter (mg/d), though exact ranges vary by lab and population

What can a uric acid test tell you?

A uric acid test can help healthcare providers:

  • Evaluate gout: Identify or monitor elevated uric acid when joint pain, redness, or swelling suggests gout. However, elevated uric acid levels (hyperuricemia) do not necessarily mean a person will develop gout, as many individuals with hyperuricemia never experience gout symptoms.

  • Assess kidney health: Detect decreased uric acid clearance due to kidney disease.

  • Monitor treatment: Track uric-acid–lowering medications such as allopurinol or febuxostat.

  • Evaluate chemotherapy side effects: Identify tumor-lysis syndrome, when rapid cell breakdown releases excess uric acid into the blood (NCI).

What is being tested?

Uric acid is the final breakdown product of purine metabolism (the breakdown of purines). Normally, it dissolves in blood and is filtered by the kidneys into urine. When too much uric acid is produced or too little is excreted, blood levels rise, a condition called hyperuricemia.

If levels stay high, sharp, needle-shaped crystals can deposit in joints, soft tissues, or kidneys, leading to gout attacks or stones.

Where is the uric acid test typically included?

A uric acid test may be ordered:

  • As part of a renal function panel (to evaluate kidney health).

  • Alongside a metabolic panel.

  • In oncology panels to monitor tumor lysis syndrome during chemotherapy.

Commonly measured with:

  • Creatinine and eGFR (for kidney filtration).

  • BUN (blood urea nitrogen).

  • 24-hour urinary uric acid (to assess excretion rate).

Who should get a uric acid test?

Your provider may recommend testing if you:

  • Have sudden joint pain, swelling, or redness (possible sign of a gout attack).

  • Experience recurrent kidney stones.

  • Have chronic kidney disease or decreased kidney function.

  • Are receiving chemotherapy or radiation for cancer.

  • Take medications that can raise uric acid (e.g., diuretics, low-dose aspirin).

  • Experience obesity, diabetes, or metabolic syndrome, all of which can increase your risk of hyperuricemia.

Uric acid is not a routine screening and isn’t generally recommended for people without symptoms or risk factors. However, uric acid levels are often measured incidentally during annual checkups, hospital stays, or when monitoring conditions like kidney disease, gout, or metabolic syndrome.

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Not available in all 50 states. Eligibility and provider order required. Lab results alone are not intended to diagnose, treat, or cure any condition. A provider will reach out about critical results and plans include access to 24/7 provider messaging.

Images for illustrative purposes only.

Frequently asked questions

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What causes changes in uric acid levels?

Increased levels can result from a high-purine diet (red meat, shellfish, organ meats), alcohol use, obesity, dehydration, or certain medications (thiazide diuretics, niacin, cyclosporine). Kidney disease, poor uric acid excretion, or rapid cell turnover from conditions like chemotherapy, leukemia, or psoriasis can also contribute.

Causes of decreased levels include low purine intake or malnutrition; certain kidney tubular disorders; liver disease; medications (including uricosuric agents, or estrogen therapy); and SIADH (syndrome of inappropriate antidiuretic hormone). 

Can this test be done at home?

Yes. Some at-home finger-prick or mail-in kits measure uric acid, but accuracy may vary. Telehealth providers can interpret results and recommend follow-up labs if needed.

What are the screening recommendations for uric acid?

Testing is typically ordered for people with gout symptoms, kidney stones, or kidney-function concerns.

What are normal reference ranges for uric acid?

A healthy range (measured in milligrams per deciliter): Generally, for adult men,  it’s 4.0- 8.0 mg/d, though exact ranges vary by lab and population

Do I need to fast before the test?

Fasting is not usually required, though some labs ask you to avoid alcohol or heavy meals before testing.

How long do results take?

Most labs return results within one to three business days.

How often should I get tested?

The frequency of testing depends on your condition. People with gout or chronic kidney disease may need testing every few months, while others may only need it as needed.

Does high uric acid always mean gout?

Not necessarily. Many people with hyperuricemia never develop gout.

Can I lower uric acid naturally?

Hydration, limiting purine-rich foods and alcohol, and maintaining a healthy weight can all help. A provider can determine if medication is also necessary.

Does insurance cover uric acid testing?

Most insurance plans cover uric acid testing when medically indicated. However, insurance is not required with lab testing through Hims. 

What tests are related to this biomarker?

Creatinine and eGFR (kidney function)

• 24-hour urinary uric acid

• Basic or comprehensive metabolic panel

• Joint fluid (synovial) analysis for urate crystals

Blood urea nitrogen (BUN)

• C-reactive protein (CRP) or ESR for inflammation

The information provided here is for informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always talk to a qualified healthcare provider about your specific health concerns.

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Reviewed by Lynn Marie Morski, MD

Published 11/19/2025