Paroxetine for PE

Meet Paroxetine

  • Daily pill that can be taken for climax control
  • Helps you last 9-12x longer in bed
  • No doctor’s office visit required
  • Free, discreet delivery, if prescribed

How it Works

PE keeping you down? Paroxetine is a selective serotonin reuptake inhibitor (SSRI) that can be taken daily to increase climax control and overall performance in bed. A great option for guys who don’t want to mess with extra steps, wipes or sprays when the mood strikes.

The Fine Print

Paroxetine is approved by the FDA to treat depression, anxiety and certain other conditions, but has not been specifically approved to treat premature ejaculation. A medical provider can prescribe it if they determine it is safe and appropriate for your condition. Prescription products available only if prescribed by the healthcare provider after an online consultation. This page was medically reviewed by Peter J. Stahl, MD.

Important Safety Information


Paroxetine and other antidepressant drugs may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Pay particular attention to such changes when paroxetine is started or when the dose is changed.

Do not take paroxetine if:

You take a Monoamine Oxidase Inhibitor (MAOI), including linezolid or methylene blue, or if you stopped taking an MAOI in the last 2 weeks. Do not take an MAOI within 2 weeks of stopping paroxetine. Ask your healthcare provider or pharmacist if you are not sure if your medicine is an MAOI. People who take paroxetine close in time to an MAOI may have serious or even life threatening side effects.

Get medical help right away if you have any of these symptoms:

  • high fever
  • uncontrolled muscle spasms
  • stiff muscles
  • rapid changes in heart rate or blood pressure
  • confusion
  • loss of consciousness (pass out)

Take Orap® (pimozide) because this can cause serious heart problems

Take MELLARIL® (thioridazine) because this can cause serious heart rhythm problems or sudden death.

Are allergic to paroxetine or any of the inactive ingredients in paroxetine

Paroxetine and other antidepressant medicines may cause serious side effects. Call a healthcare provider right away if you or a person you know who is taking paroxetine has any of the following symptoms, especially if they are new, worse, or worry you:

  • Attempts to commit suicide
  • Acting aggressive or violent
  • New or worse depression
  • Feeling agitated, restless, angry, or irritable
  • An increase in activity or talking more than what is normal for you
  • Acting on dangerous impulses
  • Thoughts about suicide or dying
  • New or worse anxiety or panic attacks
  • Trouble sleeping
  • Other unusual changes in behavior or mood

Depression or other serious mental illnesses are the most important causes of suicidal thoughts or actions. Watch for these changes and call your healthcare provider right away if you notice new or sudden changes in mood, behavior, actions, thoughts, or feelings, especially if severe. Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms.

Before taking paroxetine, tell your healthcare provider and pharmacist about all prescription and over-the-counter medications and supplements you take or plan to take including:

  • those to treat migraines
  • psychiatric disorders (including other antidepressants or amphetamines) to avoid a potentially life-threatening condition called serotonin syndrome
  • Aspirin
  • other NSAID pain relievers
  • other blood thinners because they may increase the risk of bleeding
  • drugs used to treat irregular heartbeat
  • drugs used to treat HIV infection
  • drugs used to treat epilepsy

Before taking paroxetine, tell your healthcare provider your complete list of medical conditions, including if you have liver problems, kidney problems, heart problems, seizures or convulsions, psychiatric disorders including bipolar disorder or mania, low sodium levels in your blood, history of a stroke, high blood pressure, bleeding problems, or glaucoma (high pressure in the eye).

Tell your healthcare provider immediately if you

  • Become severely ill and have some or all of these symptoms: agitation, hallucinations, coma, or other changes in mental status; coordination problems or muscle twitching (overactive reflexes); racing heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting, or diarrhea; muscle tightness, as these may be the symptoms of a life-threatening condition called Serotonin Syndrome
  • Have a rash, hives, swelling, or trouble breathing as these may be the symptoms of an allergic reaction
  • Have seizures or convulsions
  • Have any increased or unusual bruising or bleeding, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAID), or aspirin
  • Have a headache; weakness or feeling unsteady; confusion, problems concentrating, thinking, or remembering, as these may be the symptoms of low salt (sodium) levels in the blood (hyponatremia). Elderly people may be at greater risk for this

Do not stop paroxetine without first talking to your healthcare provider. Stopping paroxetine may cause serious symptoms, including anxiety, irritability, high or low mood, feeling restless or sleepy; headache, sweating, nausea, dizziness; electric shock-like sensations, shaking, and confusion.

Some people are at risk for visual problems such as eye pain, changes in vision, or swelling or redness around the eye. You may want to undergo an eye examination to see if you are at risk and get preventative treatment if you are.

Should I avoid any activities while taking paroxetine?

Paroxetine can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how paroxetine affects you.

Drinking alcohol while taking paroxetine is not recommended.

What are the possible side effects of paroxetine in adults?

The most common side effects in adults treated with paroxetine include:

  • Nausea, loss of appetite, diarrhea, or indigestion
  • Increased sweating
  • Tremor or shaking
  • Agitation
  • Change in sleep habits including increased sleepiness or insomnia
  • Sexual problems including decreased libido and ejaculation failure
  • Feeling tired or fatigued
  • Weakness
  • Dizziness
  • Sexual problems
  • Dry mouth
  • Constipation
  • Infection
  • Feeling anxious or trouble sleeping

Contact your healthcare provider if you have any side effect that continues or bothers you. These are not all the possible side effects of paroxetine. Contact your healthcare provider or pharmacist if you need more information.

For medical advice on side effects, contact your healthcare provider. You can also report side effects to the FDA at 1-800-FDA-1088.

Your healthcare provider or pharmacist can tell you if it is safe to take paroxetine with your other medicines. Do not start or stop any medicine while taking paroxetine without talking to your healthcare provider first.

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Paroxetine for PE

The reinforcements are here

When it comes to treating PE, you’ve got options


This pill can be prescribed for the treatment of premature ejaculation. This prescription medication gives you more control over climax and helps you last longer in bed—the result? Better, longer lasting sex. Studies have shown sertraline to increase time to climax up to 5x for people struggling with PE.


This pill can be taken as needed before sex to help manage premature ejaculation. Studies also suggest it can decrease the amount of time it takes to get a second erection, so you and your partner can go for another round, if you like. While not FDA-approved for the treatment of PE, a medical provider can prescribe it if they feel it’s safe and appropriate.

Climax Delay Spray

This spray reduces sensitivity where you need it to. With just a few quick spritzes, the active ingredient (lidocaine) quickly absorbs into skin so you and your partner can get the most out of your time together.

Additional fees may apply

Trusted by doctors

Peter J. Stahl, MD

Men’s Reproductive &
Sexual Health

The same trusted medication and treatment you’d find at the doctor’s office—100% online and delivered to your door, if prescribed.

Peter J. Stahl, MD

Men’s Reproductive &
Sexual Health