Enclomiphene, or enclomiphene citrate, is an oral medication that helps restore natural testosterone production in men with a form of low testosterone called secondary hypogonadism by signaling the body to make more testosterone and sperm. It supports healthy hormone levels without suppressing sperm count, making it a fertility-friendly option for men with low testosterone.1
1. Thomas, J., Suarez Arbelaez, M. C., Narasimman, M., Weber, A. R., Blachman-Braun, R., White, J. T., Ledesma, B., Ghomeshi, A., Jara-Palacios, M. A., & Ramasamy, R. (2023). Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus, 15(7), e41476. Source.
There is limited research on the side effects of enclomiphene. Common side effects include headache, hot flashes, mood changes or irritability, nausea or upset stomach, breast tenderness, and fatigue.
If you notice any serious side effects, seek medical care immediately. These include vision changes, floaters, or vision loss; severe or persistent headaches; signs of blood clots (leg swelling, chest pain, shortness of breath); mood changes, depression, mania, or new psychiatric symptoms; signs of liver problems (yellowing skin/eyes, dark urine, abdominal pain); swelling, rapid weight gain, or fluid retention; polycythemia; and new or worsening cancer symptoms.
Yes, enclomiphene increases testosterone levels in men with secondary hypogonadism by stimulating the body’s natural testosterone production. It’s an effective option for restoring testosterone while maintaining fertility2 and supporting natural sperm production.
2. Thomas, J., Suarez Arbelaez, M. C., Narasimman, M., Weber, A. R., Blachman-Braun, R., White, J. T., Ledesma, B., Ghomeshi, A., Jara-Palacios, M. A., & Ramasamy, R. (2023). Efficacy of Clomiphene Citrate Versus Enclomiphene Citrate for Male Infertility Treatment: A Retrospective Study. Cureus, 15(7), e41476. Source.
Enclomiphene has not been studied extensively, but in one study, it was shown to increase total testosterone levels in men with secondary hypogonadism in as little as two weeks. The study was a randomized study of enclomiphene citrate in 44 men with secondary hypogonadism for 6 weeks.3
3. Wiehle, R., Cunningham, G. R., Pitteloud, N., Wike, J., Hsu, K., Fontenot, G. K., Rosner, M., Dwyer, A., & Podolski, J. (2013). Testosterone Restoration by Enclomiphene Citrate in Men with Secondary Hypogonadism: Pharmacodynamics and Pharmacokinetics. BJU international, 112(8), 1188–1200. Advance online publication. Source.
No, enclomiphene is not FDA-approved and has not been evaluated for safety, effectiveness, or quality. While clomiphene is approved by the U.S. Food and Drug Administration (FDA) for use in women, enclomiphene remains investigational and is only available through compounding pharmacies or clinical trials.
Enclomiphene is not known to cause hair loss directly, and hair loss is not listed among the medication’s reported side effects.
Hims offers access to a daily oral medication that contains just enclomiphene or combines enclomiphene with tadalafil. The medication containing tadalafil offers a treatment plan for patients with a clinical need to boost testosterone production and help with erectile function. Treatments are offered in 3-, 5-, or 10-month plans.
No, Hims does not currently offer access to TRT injections.
Pricing for low testosterone treatment with enclomiphene through Hims starts at $99/month for a 10-month plan paid upfront and in full.
Insurance isn’t required, so there are no complicated insurance questions or health insurance plan considerations.