Bupropion

Your safety is our first priority. Learn more about key medication details, side effects, and other important info about your treatment.

Bupropion is approved by the FDA for the treatment of major depressive disorder. Healthcare providers have the discretion to prescribe a medication for other uses as part of the practice of medicine.

Prescribing information
Common Side effects

  • Anxiety

  • Insomnia

  • Nervousness

Important safety information

BUPROPION XL (Wellbutrin XL©) is a prescription medicine that is FDA approved to treat adults with a certain type of depression called major depressive disorder, and for the prevention of autumn-winter seasonal depression (seasonal affective disorder).

When prescribed off-label Bupropion may help some adults with overweight and obesity lose weight and keep the weight off.

Do not take Bupropion if you:

  • Are allergic to Bupropion, or any of the ingredients in Bupropion

  • Have severe liver or kidney problems

  • Have benzodiazepine dependence

  • Take any medicines for Parkinson’s Disease or depression called monoamine oxidase inhibitors (MAOI), or if you have stopped taking an MAOI in the last 14 days as they may cause a dangerous increase in blood pressure. MAOIs include, but are not limited to:

    • isocarboxazid

    • phenelzine

    • rasagiline

    • selegiline

    • tranylcypromine

  • Take other medication that may cause an increase in serotonin levels, such as

    • linezolid

    • methylene blue

    • tryptophan

Before taking Bupropion, inform your healthcare provider and pharmacist about all prescription medications you are taking or plan to take, including those to treat Parkinson’s Disease or psychiatric disorders (including antidepressants or amphetamines) to avoid a potentially life-threatening condition called Serotonin Syndrome or a dangerous increase in blood pressure. Inform your healthcare provider about any over-the-counter medications, vitamins, and natural supplements, such as St. John’s Wort, that you are taking or plan to take to help avoid potentially dangerous drug-drug interactions. Be sure to mention to your prescriber if you drink grapefruit juice or eat grapefruit regularly.

Inform your healthcare provider immediately if you:

  • Become severely ill and have some or all of these symptoms: agitation, hallucinations, coma, or other changes in mental status; coordination problems or muscle twitching (overactive reflexes); racing heartbeat, high or low blood pressure; sweating or fever; nausea, vomiting, or diarrhea; muscle tightness, as these may be the symptoms of a life-threatening condition called Serotonin Syndrome

  • Develop restlessness or an inability to remain still, involuntary movements, hostility, or depression

  • Have a rash, hives, swelling, or trouble breathing as these may be the symptoms of an allergic reaction

  • Are pregnant, plan to become pregnant, or are breastfeeding

Do not stop daily Bupropion without first talking to your healthcare provider. Abruptly stopping can cause withdrawal symptoms including: vomiting, irritability, dizziness, headaches, sensation of tingling skin, or trouble sleeping.

Until you experience how this medication affects you, do not drive a car, operate potentially dangerous machinery, or perform other dangerous activities.

You should take Bupropion consistently, either always with or always without food.

During your treatment with Bupropion, avoid drinking large amounts of grapefruit juice.

Avoid drinking alcohol while taking Bupropion.

The most common side effects in adults treated with Bupropion include:

  • Dizziness

  • Drowsiness

  • Diarrhea

  • Nausea

  • Headache

  • Insomnia

  • Mild congestion

  • A very rare but serious side effect that may occur with Bupropion therapy is serotonin syndrome. The symptoms of serotonin syndrome include, but are not limited to, a change in mental status, trouble speaking or swallowing, excessive sweating, tremors, involuntary muscle contractions, and increased body temperature. Seek emergent medical care if you are experiencing any of these symptoms as they could be a sign of a life-threatening condition.

If you miss a dose of Bupropion, take it as soon as you remember. However, if it is almost time for your next dose, then skip the missed dose and continue your regular dosing schedule. Do not double your next dose or take more than what is prescribed.